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Revision as of 15:51, 10 May 2023

CD43 sialophorin has a wide range of expression that includes t lymphocytes monocytes and granulocytes. CD43 is expressed by many normal activated b lymphocytes but expression is absent from resting B cells. Diagnostically the vlaue of CD43 relates to its variable expression between B lymphocyte neoplasms. usage

CD43 expression in CLL is 95% including atypical CLL cases while in MCL it is expressed by around 40% of cases.
this gives it some value in diagnosing cases of atypical CLL
however CD43 is probably less useful than CD200 for distinguishing CLL and MCL.
CD43 is rarely expressed in follicular lymphoma.

note also in haematopathology CD43 is often considered as a t-cell associated marker because it is expressed by over 95 of thymocytes and peripheral blood t-cells. loss of CD43 is seen in wiskottu aldrich syndrome. ---- '),

'CD41', ' a reliable and specific marker that can be used to identify megakaryocyte lineage characteristics *CD41 and CD61 respectively represent the alpha or beta chains that together form the iibiiia receptor that allows activated platelets to bind fibrinogen and other adhesion proteins during platelet aggregation.

CD41 the alpha iib only forms part of this receptor and therefore has good specificity for megakaryocytic differentiation ---- '),

'CD61', ' a marker of megakaryocytic lineage but also expressed by cells of monocyte macrophage lineage details *CD61 is the beta integrin beta iii chain of the platelet iibiiia adhesion receptor. *CD61 may therefore be regarded as a marker of megakaryocytic lineage. however when combined with an alternative alpha chain alpha v CD61 forms part of the vitronectin receptor. the vitronectin receptor is expressed on a range of cell types including cells of monocyte macrophage lineage. *therefore while both CD41 and CD61 have value in confirming a megakaryocytic differentiation in acute myeloid leukaemia the context of its expression is important for interpretation ---- '),

@@ Line 1: / Line 1: @@
-:CD22 expression is largely restricted to B-lymphocytes
+CD43 sialophorin has a wide range of expression that includes t lymphocytes monocytes and granulocytes. CD43 is expressed by many normal activated b lymphocytes but expression is absent from resting B cells.
-:Expression varies during mature b-cell development, however the major value of CD22 lies in the identification of ALL
+Diagnostically the vlaue of CD43 relates to its variable expression between B lymphocyte neoplasms.
-:This value is based on high lineage-specificity and very early acquisition in cytoplasm then cell surface
+usage
+*CD43 expression in CLL is 95% including atypical CLL cases while in MCL it is expressed by around 40% of cases.
+*this gives it some value in diagnosing cases of atypical CLL
+*however CD43 is probably less useful than CD200 for distinguishing CLL and MCL.
+*CD43 is rarely expressed in follicular lymphoma.
+note also in haematopathology CD43 is often considered as a t-cell associated marker because it is expressed by over 95 of thymocytes and peripheral blood t-cells. loss of CD43 is seen in wiskottu aldrich syndrome. ---- '),
-normal expression and function
+'CD41', ' a reliable and specific marker that can be used to identify megakaryocyte lineage
+characteristics  *CD41 and CD61 respectively represent the alpha or beta chains that together form the iibiiia receptor that allows activated platelets to bind fibrinogen and other adhesion proteins during platelet aggregation.
+*CD41 the alpha iib only forms part of this receptor and therefore has good specificity for megakaryocytic differentiation ---- '),
-CD22 is a membrane adhesion receptor whose expression is mostly restricted to B lymphocytes where it is believed to be a negative regulator of activation. Expression is developmentally related - first appearing in cytoplasm of pro-B cells then on the surface in pre-B cells. CD22 is fully expressed by mature-B cells, but is lost during plasma cell differentiation. Basophils express CD22.
+'CD61', ' a marker of megakaryocytic lineage but also expressed by cells of monocyte macrophage lineage
-other relevant information
+details  *CD61 is the beta integrin beta iii chain of the platelet iibiiia adhesion receptor. *CD61 may therefore be regarded as a marker of megakaryocytic lineage. however when combined with an alternative alpha chain alpha v CD61 forms part of the vitronectin receptor. the vitronectin receptor is expressed on a range of cell types including cells of monocyte macrophage lineage. *therefore while both CD41 and CD61 have value in confirming a megakaryocytic differentiation in acute myeloid leukaemia the context of its expression is important for interpretation ---- '),
-The restricted expression of CD22 makes it a potential therapeutic target in B cell disorders
-diagnostic role
-*Cytoplasmic expression of CD22 gives particular value in the detection of pro-B ALL where diagnosis requires expression at least two of: CD22 (membrane or cytoplasm), CD19 or CD79a. CD22 may not be uniformly expressed across a cell population with expression often being seen on only 60-90 of cells
-*in mature B cell neoplasms CD22 has relatively low expression in CLL, MCL and FL, but has high expression in HCL
- ----  summary tables
-. expression by acute leukaemias and by haematogones file freqepng  pro-b all  link flow cytometry key file hiepng  early pre-b all  link flow cytometry key file hiepng  pre-b all  link flow cytometry key file hiepng  early b all  link flow cytometry key file rareepng  pro-t all  link flow cytometry key file rareepng  mature-t all  link flow cytometry key file rareepng  aml  link flow cytometry key file hiepng  haemato-gones  link flow cytometry key  *basophils are recognised to express CD22
-. expression by b-lymphoproliferative disorders file hiepng frame  cll * link flow cytometry key file hiepng  pll**  link flow cytometry key file hiepng  mcl  link flow cytometry key file hiepng  fl  * link flow cytometry key file hiepng  hcl**  link flow cytometry key file hiepng  hclv  link flow cytometry key file hiepng  mzl  link flow cytometry key file hiepng  lpl  link flow cytometry key file possepng  pcs  link flow cytometry key  *  typically weak  **  typically strong

Extra: Difference between revisions

From haematologyetc.co.uk

Revision as of 15:51, 10 May 2023