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A T cell marker that has value in specific circumstances
CD22 expression is largely restricted to b cell lineage and expression is acquired at an early differentiation stage.
*expression varies during mature b-cell development however the major value of CD22 lies in the identification of all based on high lineage-specificity and very early acquisition allowing the identification of pro-b all. 


Background
normal expression and function 
CD1a is structurally related to major histocompatibility complex proteins and is thought to mediate the presentation of lipid and glycolipid antigens. CD1a expression is absent on very early thymocytes, but is acquired together with CD4 and CD8 as T cells develop in the thymus, then is lost in mature T cells.  
CD22 is a membrane receptor that binds sialic acid containing glycans and expression is mostly restricted to b cells where it is believed to be a negative regulator of activation. expression is developmentally related - first appearing in cytoplasm then on the surface in pre-b cells CD22 is fully expressed by mature b cells but lost on plasma cell differentiation. basophils express CD22.


Diagnostic Use
other relevant information 
:A marker of early T-lineage
as a result of its restricted expression CD22 has emerged as a therapeutic target in acute lymphoblastic leukemia all and other b cell disorders. 
:CD1A us useful in the identification of some cases of T-all and for showing T lineage in MPAL
 
:Expression is notably absent in ETP-ALL
diagnostic role 
*its early cytoplasmic expression gives CD22 particular value in the detection of pro b-all diagnosis requires expression of two of the following three markers CD22 membrane or cytoplasm ; CD19 or CD79a. CD22 may not be uniformly expressed across the population with expression being seen on 60-90 of cells.
*in mature b cell neoplasms CD22 has relatively low expression in cll mcl and fcl but has markedly increased expression in hcl and related disorders.
 
----  summary tables 
1. expression by acute leukaemias and by haematogones file freqepng  pro-b all  link flow cytometry key file hiepng  early pre-b all  link flow cytometry key file hiepng  pre-b all  link flow cytometry key file hiepng  early b all  link flow cytometry key file rareepng  pro-t all  link flow cytometry key file rareepng  mature-t all  link flow cytometry key file rareepng  aml  link flow cytometry key file hiepng  haemato-gones  link flow cytometry key  *basophils are recognised to express CD22 
2. expression by b-lymphoproliferative disorders file hiepng frame  cll * link flow cytometry key file hiepng  pll**  link flow cytometry key file hiepng  mcl  link flow cytometry key file hiepng  fl  * link flow cytometry key file hiepng  hcl**  link flow cytometry key file hiepng  hclv  link flow cytometry key file hiepng  mzl  link flow cytometry key file hiepng  lpl  link flow cytometry key file possepng  pcs  link flow cytometry key  *  typically weak  **  typically strong ----

Revision as of 10:55, 9 May 2023

CD22 expression is largely restricted to b cell lineage and expression is acquired at an early differentiation stage.

  • expression varies during mature b-cell development however the major value of CD22 lies in the identification of all based on high lineage-specificity and very early acquisition allowing the identification of pro-b all.

normal expression and function CD22 is a membrane receptor that binds sialic acid containing glycans and expression is mostly restricted to b cells where it is believed to be a negative regulator of activation. expression is developmentally related - first appearing in cytoplasm then on the surface in pre-b cells CD22 is fully expressed by mature b cells but lost on plasma cell differentiation. basophils express CD22.

other relevant information as a result of its restricted expression CD22 has emerged as a therapeutic target in acute lymphoblastic leukemia all and other b cell disorders.

diagnostic role

  • its early cytoplasmic expression gives CD22 particular value in the detection of pro b-all diagnosis requires expression of two of the following three markers CD22 membrane or cytoplasm ; CD19 or CD79a. CD22 may not be uniformly expressed across the population with expression being seen on 60-90 of cells.
  • in mature b cell neoplasms CD22 has relatively low expression in cll mcl and fcl but has markedly increased expression in hcl and related disorders.
----  summary tables  
1. expression by acute leukaemias and by haematogones file freqepng  pro-b all  link flow cytometry key file hiepng  early pre-b all  link flow cytometry key file hiepng  pre-b all  link flow cytometry key file hiepng  early b all  link flow cytometry key file rareepng  pro-t all  link flow cytometry key file rareepng  mature-t all  link flow cytometry key file rareepng  aml  link flow cytometry key file hiepng  haemato-gones  link flow cytometry key  *basophils are recognised to express CD22  

2. expression by b-lymphoproliferative disorders file hiepng frame  cll * link flow cytometry key file hiepng  pll**  link flow cytometry key file hiepng  mcl  link flow cytometry key file hiepng  fl  * link flow cytometry key file hiepng  hcl**  link flow cytometry key file hiepng  hclv  link flow cytometry key file hiepng  mzl  link flow cytometry key file hiepng  lpl  link flow cytometry key file possepng  pcs  link flow cytometry key  *  typically weak  **  typically strong ----
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