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Revision as of 22:55, 8 May 2023

CD1a

a marker of early t-lineage that is useful for the identification of some cases of t-all expression is notably absent in etp-all

CD1a may be useful to confirm t-lineage in some cases of mpal

details CD1a is structurally related to major histocompatibility complex proteins and is thought to mediate the presentation of lipid and glycolipid antigens. CD1a expression is absent on very early thymocytes but is acquired together with CD4 and CD8 as t cells develop in the thymus; expression precedes CD3. CD1a expression is lost at the mature t cell stage.

in t-all CD1a is absent at early developmental stages pro-t and pre-t and is not expressed by etp-all early-t precursor all .
CD1a is expressed by cortical t cells so expression of CD1a on leukaemic cells can contribute to a diagnosis of t-all or to the identification of t-lineage in mpal

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-'cd1a', ' *au800 marker ofu800 early tu800-lineage that isu800 useful foru800 theu800 identification ofu800 some cases ofu800 tu800-allu800 expression isu800 notably absent inu800 etpu800-allu800 *cd1a mayu800 beu800 useful tou800 confirm tu800-lineage inu800 some cases ofu800 mpal  details  cd1a isu800 structurally related tou800 major histocompatibility complex proteins andu800 isu800 thought tou800 mediate theu800 presentation ofu800 lipid andu800 glycolipid antigens. cd1a expression isu800 absent onu800 very early thymocytes butu800 isu800 acquired together with cd4u800 andu800 cd8u800 asu800 tu800 cells develop inu800 theu800 thymus; expression precedes cd3u800. cd1a expression isu800 lost atu800 theu800 mature tu800 cell stage. *inu800 tu800-allu800 cd1a isu800 absent atu800 early developmental stages prou800-tu800 andu800 preu800-tu800 andu800 isu800 notu800 expressed byu800 etpu800-allu800 early-tu800 precursor allu800 . *cd1a isu800 expressed byu800 cortical tu800 cells sou800 expression ofu800 cd1a onu800 leukaemic cells canu800 contribute tou800 au800 diagnosis ofu800 tu800-allu800 oru800 tou800 theu800 identification ofu800 tu800-lineage inu800 mpal ----
+CD1a
+*a marker of early t-lineage that is useful for the identification of some cases of t-all expression is notably absent in etp-all
+*CD1a may be useful to confirm t-lineage in some cases of mpal
+details  CD1a is structurally related to major histocompatibility complex proteins and is thought to mediate the presentation of lipid and glycolipid antigens. CD1a expression is absent on very early thymocytes but is acquired together with CD4 and CD8 as t cells develop in the thymus; expression precedes CD3. CD1a expression is lost at the mature t cell stage.
+*in t-all CD1a is absent at early developmental stages pro-t and pre-t and is not expressed by etp-all early-t precursor all .
+*CD1a is expressed by cortical t cells so expression of CD1a on leukaemic cells can contribute to a diagnosis of t-all or to the identification of t-lineage in mpal

Extra: Difference between revisions

From haematologyetc.co.uk

Revision as of 22:55, 8 May 2023