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CD2
CD10


CD2 is a pan t-cell marker. In diagnostic use it may be less reliable than CD3 for identification of T-cell lineage, since loss of CD2 expression is seen in some peripheral T-cell lymphomas, and aberrant expression in AML is recognised (particularly the APL subtype).   
* CD10  expressed  early pre-b all but also has wide expression on all subtypes notably also on burkitt lymphoma and many cases of t-all
*CD10  also found on normal developing b-lymphocytes haematogones which may be very frequent  regenerating marrows
* lymphoproliferative disorders CD10  consistently expressed by follicular lymphoma but may rarely be found on other lymphoproliferative cell types.   




normal expression and function   
normal expression and function
 
the function of CD10  to inactivate small peptide hormones; however no single distinct function has been identified within the haematopoietic system u8e28093  particular CD10 seems to have different roles within the lymphoid and myeloid systems. CD10  widely expressed by hematopoietic cell types.  lymphoid cells expression broadly correlates with periods of proliferation iee. it  expressed from the early pre-b cell stage then  lost as b cells leave the bone marrow then re-acquired by b cells within the reactive germinal centres iee. secondary follicles .  contrast  the myeloid system CD10  expressed on mature neutrophils but not maturing myeloid cells .  


CD2 forms part of the T-cell receptor complex, mediating adhesion to accessory cells and assisting in the generation and control of intracellular signal transduction. Expression of CD2 is acquired during early T cell ontogeny, preceded by CD7 and cytoplasmic CD3 expression and is then retained through thymic maturation and by peripheral t cells. CD2 is also expressed only by a proportion of normal mast cells but is frequently expressed in systemic mastocytosis. 


diagnostic role 


1.  lymphoproliferative disorders  CD10  considered to be a marker of follicular lymphoma where expression  consistent and strong. however other lymphoproliferative disorders cll hcl mcl lpl mzl pcl all may express CD10 occasionally 10 . 


what is its diagnostic role   
2.  acute leukaemia  b lineage all CD10  absent from pro-b all but  consistently expressed by later forms particularly early pre-b all common all and most cases of burkitt lymphoma;  pre-b all CD10 may not be expressed. approximately 30 of cases of t-all express CD10 but expression  aml  rare. 


CD2 generally identifies T-cell lineage and is not expressed by normal B-cells  
3. haematogones  the primitive maturing b cells of regenerating marrow consistently express CD10 at all stages of their maturation it  important to distinguish these from all. 
* In T-ALL and peripheral T-cell lymphomas CD2 may contribute to diagnosis, but loss of expression is recognised
* CD2 and CD7 are expressed by NK cells (in contrast to CD3) and may be used together with CD56 to identify NK cells
* In systemic mastocytosis CD2 (with or without CD25) is expressed on the abnormal mast cell population, and in a proportion of cases CD25 may provide greater sensitivity and specificity




other relevant information    histopathology CD10 expression  important  a range of diagnoses including many solid tumour types.  lymphoma it  particularly valuable  the recognition of angioimmunoblastic t cell lymphoma aitl and for dlbcl abc type .


summary tables 


 
summary tables  expression by acute leukaemias and by haematogones file rareepng pro-b all link flow cytometry key file hiepng early pre-b all link flow cytometry key file freqepng pre-b all link flow cytometry key file freqepng b all link flow cytometry key file rareepng pro-t all link flow cytometry key file possepng mature-t all link flow cytometry key file rareepng aml  link flow cytometry key file hiepng haemato-gones  * link flow cytometry key expression by b-lymphoproliferative disorders file possepng frame  cll link flow cytometry key file possepng pll link flow cytometry key file possepng mcl link flow cytometry key file hiepng fl link flow cytometry key file possepng hcl link flow cytometry key file possepng hclv link flow cytometry key file possepng mzl link flow cytometry key file possepng lpl link flow cytometry key file possepng pcs link flow cytometry key  *  typical of fl ----  key the indicated expression frequency indicates the approximate frequency of occurrence  each particular disease type. file rareepng 30px link rare 5 file possepng 30px link possible 5-20 file modepng 30px link likely 20-40 file freqepng 30px link frequent 40-80 file hiepng 30px link expected 80 where expression level  unusual or characteristic of a disorder this indicated by text '),
expression by acute leukaemias and by haematogones  
 
file rar.png pro-b all   key file rar.png early pre-b all   key file rar.png pre-b all   key file rar.png b all   key file hiu82epng pro-t all   key file hiu82epng mature-t all   key file possu82epng aml  *  key file rar.png haemato-gones   key  
 
* recognised expression in aml particularly apml
 
 
expression by b-lyphoproliferative disorders  
 
file modu82epng frame  cll*  key file rar.png pll   key file rar.png mcl   key file rar.png fl   key file rar.png hcl   key file rar.png hclv   key file rar.png mzl   key file rar.png lpl   key file rar.png pcs  
 
expression is recognised in most b-lpd but generally 5 of cases  
* expression is recognised in cll overall around 20 of cases
expression by mature t-cell disorders file hiu82epng frame t-pll

Revision as of 11:21, 7 May 2023

CD10

  • CD10 expressed early pre-b all but also has wide expression on all subtypes notably also on burkitt lymphoma and many cases of t-all
  • CD10 also found on normal developing b-lymphocytes haematogones which may be very frequent regenerating marrows
  • lymphoproliferative disorders CD10 consistently expressed by follicular lymphoma but may rarely be found on other lymphoproliferative cell types.


normal expression and function

the function of CD10 to inactivate small peptide hormones; however no single distinct function has been identified within the haematopoietic system u8e28093 particular CD10 seems to have different roles within the lymphoid and myeloid systems. CD10 widely expressed by hematopoietic cell types. lymphoid cells expression broadly correlates with periods of proliferation iee. it expressed from the early pre-b cell stage then lost as b cells leave the bone marrow then re-acquired by b cells within the reactive germinal centres iee. secondary follicles . contrast the myeloid system CD10 expressed on mature neutrophils but not maturing myeloid cells .


diagnostic role

1. lymphoproliferative disorders CD10 considered to be a marker of follicular lymphoma where expression consistent and strong. however other lymphoproliferative disorders cll hcl mcl lpl mzl pcl all may express CD10 occasionally 10 .

2. acute leukaemia b lineage all CD10 absent from pro-b all but consistently expressed by later forms particularly early pre-b all common all and most cases of burkitt lymphoma; pre-b all CD10 may not be expressed. approximately 30 of cases of t-all express CD10 but expression aml rare.

3. haematogones the primitive maturing b cells of regenerating marrow consistently express CD10 at all stages of their maturation it important to distinguish these from all.


other relevant information histopathology CD10 expression important a range of diagnoses including many solid tumour types. lymphoma it particularly valuable the recognition of angioimmunoblastic t cell lymphoma aitl and for dlbcl abc type .


summary tables expression by acute leukaemias and by haematogones file rareepng pro-b all link flow cytometry key file hiepng early pre-b all link flow cytometry key file freqepng pre-b all link flow cytometry key file freqepng b all link flow cytometry key file rareepng pro-t all link flow cytometry key file possepng mature-t all link flow cytometry key file rareepng aml link flow cytometry key file hiepng haemato-gones * link flow cytometry key expression by b-lymphoproliferative disorders file possepng frame cll link flow cytometry key file possepng pll link flow cytometry key file possepng mcl link flow cytometry key file hiepng fl link flow cytometry key file possepng hcl link flow cytometry key file possepng hclv link flow cytometry key file possepng mzl link flow cytometry key file possepng lpl link flow cytometry key file possepng pcs link flow cytometry key * typical of fl ---- key the indicated expression frequency indicates the approximate frequency of occurrence each particular disease type. file rareepng 30px link rare 5 file possepng 30px link possible 5-20 file modepng 30px link likely 20-40 file freqepng 30px link frequent 40-80 file hiepng 30px link expected 80 where expression level unusual or characteristic of a disorder this indicated by text '),

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