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| <span style="color:navy">'''''DETAILS'''''</span>
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| CD38 helps mobilise intracellular calcium to activate a wide array of cell functions. In haematological cell types CD38 it is widely expressed by lymphoid cells )B, T and NK) as well as myeloid precursor cells and mature myeloid cells. It has particular diagnostic importance for lymphocytes where CD38 expression is acquired as stem cells commit to B-cell lineage, then is lost as mature B cells emerge from bone marrow before being re-acquired at the time of plasma cell differentiation.
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| <span style="color:navy">'''What is its diagnostic role?'''</span>
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| The wide expression of CD38 limits its diagnostic value except in very specific circumstances:
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| *The co-expression of CD38 with CD138 can identify normal or neoplastic plasma cells
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| *Expression of CD38 in chronic lymphocytic leukaemia (>20% of cells) may associated with poorer outcome
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| <span style="color:navy">'''Other relevant information:'''</span> CD38 is a therapeutic target, daratumumab is a monoclonal antibody which binds to CD38 and is used in the treatment of myeloma.
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| <span style="color:navy">'''''SUMMARY TABLES'''''</span>
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| {| class=wikitable style="text-align: center; width: 800px;"
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| !colspan="8"|Expression of CD38 by primitive lymphoid cells: ALL and haematogones
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| ! pro-B ALL !! early pre-B ALL !!pre-B ALL!! B-ALL !!pro-T ALL !!mature-T ALL !!AML !!Haematogones
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| |style= "width: 100px; height: 20px; background: #006699; color:white"|
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| |style="width: 100px; background: #006699; color:white"|
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| |style="width: 100px; background: #006699; color:white"|
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| |style="width: 100px; background: #006699; color:white"|
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| |style="width: 100px; background: #006699; color:black"|
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| |style="width: 100px; background: #006699; color:black"|
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| |style="width: 100px; background: #00b8e6; color:white"|*
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| |style="width: 100px; background: #004466; color:white"|stg
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| |}
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| <span style="font-size:80%">''* low expression correlates with subtype e.g. APML''</span>
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| {| class=wikitable style="text-align: center; width: 800px; height 20px;"
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| !colspan="8"|Expression of CD38 by mature B cells: B-lymphoproliferative disorders
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| ! CLL !! MCL !!FL!! HCL !!HCv !!MZL!!LPL!!PCL
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| |style= "width: 100px; background: #00b8e6; color:black"|*
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| |style="width: 100px; background: #004466; color:white"|
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| |style="width: 100px; background: #004466; color:white"|**
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| |style= "width: 100px; background: #00b8e6; color:white"|
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| |style= "width: 100px; background: #00b8e6; color:white"|
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| |style="width: 100px; background: #004466; color:white"|
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| |style="width: 100px; background: #006699; color:white"|
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| |style="width: 100px; background: #004466; color:white"|stg/mod
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| |}
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| <span style="font-size:80%">''*May indicate adverse prognostic when present on more than 20% of cells''</span>
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| <span style="font-size:80%">''**May be weak''</span>
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| ----
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