CD64: Difference between revisions
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:<span style="color:navy">'''Summary'''</span> | :<span style="color:navy">'''Summary'''</span> | ||
: | :CD64 is less specific than CD14 in the identification of monocyte lineage, but is more sensitive and can be useful in the characterisation of MPAL | ||
</div> | </div> | ||
:<span style="color:navy">'''Diagnostic Use'''</span> | :<span style="color:navy">'''Diagnostic Use'''</span> | ||
* | *CD64 is less specific than CD14, but is reliably expressed in AML with monocytic differentiation either monoblastic or monocytic aml | ||
*CD64 is not expressed by normal neutrophIls, but is acquired following their activation and is consistently expressed by promyelocytic AML albeit at lower intensity than in monocytic AML | |||
*The expression of CD64 by monocytic-lineage cells means that it has particular use as an additional marker of myeloid lineage in cases of suspected mpal. | |||
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Latest revision as of 09:43, 12 October 2023
- Summary
- CD64 is less specific than CD14 in the identification of monocyte lineage, but is more sensitive and can be useful in the characterisation of MPAL
- Diagnostic Use
- CD64 is less specific than CD14, but is reliably expressed in AML with monocytic differentiation either monoblastic or monocytic aml
- CD64 is not expressed by normal neutrophIls, but is acquired following their activation and is consistently expressed by promyelocytic AML albeit at lower intensity than in monocytic AML
- The expression of CD64 by monocytic-lineage cells means that it has particular use as an additional marker of myeloid lineage in cases of suspected mpal.