CD61: Difference between revisions
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:<span style="color:navy">'''Summary'''</span> | :<span style="color:navy">'''Summary'''</span> | ||
: | :a marker of megakaryocytic lineage but also expressed by cells of monocyte macrophage lineage | ||
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:<span style="color:navy">'''Background'''</span> | :<span style="color:navy">'''Background'''</span> | ||
: | :CD61 is the beta integrin beta III chain of the platelet IIbIIIa adhesion receptor. CD61 may therefore be regarded as a marker of megakaryocytic lineage. however when combined with an alternative alpha chain alpha v CD61 forms part of the vitronectin receptor. The vitronectin receptor is expressed on a range of cell types including cells of monocyte macrophage lineage. | ||
:<span style="color:navy">'''Diagnostic Use'''</span> | :<span style="color:navy">'''Diagnostic Use'''</span> | ||
* | *Both CD41 and CD61 are valuable to confirm megakaryocytic differentiation in acute myeloid leukaemia | ||
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Revision as of 09:12, 11 May 2023
- Summary
- a marker of megakaryocytic lineage but also expressed by cells of monocyte macrophage lineage
- Background
- CD61 is the beta integrin beta III chain of the platelet IIbIIIa adhesion receptor. CD61 may therefore be regarded as a marker of megakaryocytic lineage. however when combined with an alternative alpha chain alpha v CD61 forms part of the vitronectin receptor. The vitronectin receptor is expressed on a range of cell types including cells of monocyte macrophage lineage.
- Diagnostic Use
- Both CD41 and CD61 are valuable to confirm megakaryocytic differentiation in acute myeloid leukaemia