CD56: Difference between revisions
From haematologyetc.co.uk
(Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :CD56 principally is used in the identification and classification of LGL disorders; CD56 is also expressed in some cases of myeloma and may be used in detection of MRD. </div> :<span style="color:navy">'''Background'''</span> CD56 (Neural Cell Adhesion Molecule or NCAM) as most expressed on natural killer cells, but has...") |
No edit summary |
||
Line 5: | Line 5: | ||
:<span style="color:navy">'''Summary'''</span> | :<span style="color:navy">'''Summary'''</span> | ||
:CD56 principally is used in the identification and classification of LGL disorders; CD56 is also expressed in some cases of myeloma | :CD56 principally is used in the identification and classification of LGL disorders; CD56 is also expressed in some cases of myeloma where it may be used in detection of MRD. | ||
Latest revision as of 13:20, 8 June 2023
- Summary
- CD56 principally is used in the identification and classification of LGL disorders; CD56 is also expressed in some cases of myeloma where it may be used in detection of MRD.
- Background
CD56 (Neural Cell Adhesion Molecule or NCAM) as most expressed on natural killer cells, but has been detected on other lymphoid cells including gamma delta T-cells and activated CD8 T cells as well as on dendritic cells.
- Diagnostic Use
- In myeloma a CD56 may be expressed by malignant plasma cells, but not by normal plasma cells so can be useful in disease monitoring
- In T-LGL leukaemia CD56 is variably expressed and is frequently negative, but in lymphoproliferative disorders of NK cells CD56 expression is usual