CD5

Summary

For mature B cell neoplasms: CD5 is used to indicate likely CLL or MCL. However, expression is present on a subset of normal B cells, and also less frequently on other lymphoma types. Full interpretation therefore requires consideration of clonality and other markers.

In acute lymphoblastic leukaemia: CD5 is useful to indicate T lineage, with (relatively) low levels of aberrant expression.

Normal expression and function

CD5 belongs to the scavenger-receptor cysteine rich superfamily that binds to the B-cell ligand CD72. CD5 has a negative effect on T and B cell receptor signalling, so that in B cells it raises the threshold for response to antigen (possibly limiting responses to self-antigens)

Diagnostic role

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Other relevant information:

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