CD45

SUMMARY TABLES

CD13 expression: primitive cell types
AML	B ALL	Burkitt	T ALL	ETP ALL (i)	MPAL i	Hgns i
Limited Rare Possible Likely Frequent Expected	? <5% 5-20% 20-40% 40-80% 80-100%	Possible	Rare	Likely	Likely	Possible

Notes: The main application is in AML (see notes for expression). Aberrant expression is seen in ALL - particularly in B-lineage, although it may be less likely in Burkitt lymphoma. CD13 is not generally expressed in T-ALL, but in the correct context CD13 expression can indicate MPAL or ETP-ALL. CD13 is reported to be expressed by some haematognes (click (i) for additional information)

CD13 expression: mature B cell neoplasms*
CLL	MCL	FL	MZL	HCL	LPL	PCL
rare	rare	rare	rare	rare	rare	rare

Notes: overall expression is uncommon in mature B-lymphoproliferative disorders, but may occur at plasma cell differentiation

CD13 expression: mature T cell neoplasms*
ATLL	CTCL/Sezary	T-PLL	T-LGL	NK-LGL
limited	limited	limited	limited	limited

Notes: There is limited published evidence, but reports suggest expression of CD13 is uncommon in mature T cell malignancy

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KEY

1. Colour key: - the likelihood of any individual case expressing this marker, indicated by colour:

There are few reported studies (likely <5%)

Expression is rare (<5% of cases)

Expression is seen in some cases (5-20%)

Expression is likely (20-40% of cases)

Epression is frequent (40-80%)

Expect expression in most cases (80-100%)