CD45
From haematologyetc.co.uk
SUMMARY TABLES
CD13 expression: primitive cell types | ||||||
---|---|---|---|---|---|---|
AML | B ALL | Burkitt | T ALL | ETP ALL (i) | MPAL i | Hgns i |
Limited Rare Possible Likely Frequent | Possible | Possible | Rare | Likely | Likely | Possible |
Notes: The main application is in AML (see notes for expression). Aberrant expression is seen in ALL - particularly in B-lineage, although it may be less likely in Burkitt lymphoma. CD13 is not generally expressed in T-ALL, but in the correct context CD13 expression can indicate MPAL or ETP-ALL. CD13 is reported to be expressed by some haematognes (click (i) for additional information)
CD13 expression: mature B cell neoplasms* | ||||||
---|---|---|---|---|---|---|
CLL | MCL | FL | MZL | HCL | LPL | PCL |
rare | rare | rare | rare | rare | rare | rare |
Notes: overall expression is uncommon in mature B-lymphoproliferative disorders, but may occur at plasma cell differentiation
CD13 expression: mature T cell neoplasms* | ||||||
---|---|---|---|---|---|---|
ATLL | CTCL/Sezary | T-PLL | T-LGL | NK-LGL | ||
limited | limited | limited | limited | limited |
Notes: There is limited published evidence, but reports suggest expression of CD13 is uncommon in mature T cell malignancy
KEY
1. Colour key: - the likelihood of any individual case expressing this marker, indicated by colour:
There are few reported studies (likely <5%) |
Expression is rare (<5% of cases) |
Expression is seen in some cases (5-20%) |
Expression is likely (20-40% of cases) |
Epression is frequent (40-80%) |
Expect expression in most cases (80-100%) |