CD45

Summary

CD45 is expressed by almost all mature or maturing leucocytes: hence the name leukocyte common antigen.

Usefully, the level of expression of CD45 differs according to both the cell type it is expressed on, and the maturation stage of that cell. Generally the expression for any cell type is quite consistent. This means that, when combined with other markers (particularly light scatter parameters) CD45 can be used to make a provisional identification of the different leukocyte types, allow different populations to be analysed individually.

Most frequently therefore the use of this antigen is for CD45 gating

Background

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Diagnostic Use

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