CD45: Difference between revisions
From haematologyetc.co.uk
(Created page with "<span style="color:navy">'''''SUMMARY TABLES'''''</span> {| class=wikitable style="text-align: center; font-size:80%; width: 100%; height 20px;" |- !colspan="7"|<span style="font-size:100%">'''CD13 expression: primitive cell types'''</font> |- ! AML !! B ALL !! Burkitt || T ALL !! ETP ALL ('''i''') !! MPAL '''i || Hgns '''i''' |- |style="width: 14.25%; background: #FFE4E1 #FFE4E1 #66e0ff #00b8e6 #006699; color:white"|Limited Rare Possible...") |
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! AML !! B ALL !! Burkitt || T ALL !! ETP ALL ('''[[ETP ALL|i]]''') !! MPAL '''[[MPAL|i]] || Hgns '''[[Hgns|i]]''' | ! AML !! B ALL !! Burkitt || T ALL !! ETP ALL ('''[[ETP ALL|i]]''') !! MPAL '''[[MPAL|i]] || Hgns '''[[Hgns|i]]''' | ||
|- | |- | ||
|style="width: 14.25%; background: #FFE4E1 # | |style="width: 14.25%; background: #FFE4E1 #E6FAFF #66e0ff #00b8e6 #006699; color:white black"|Limited Rare Possible Likely Frequent Expected | ||
|style="width: 14.25%; background:#66e0ff; color:black"| | |style="width: 14.25%; background: #FFE4E1 #E6FAFF #66e0ff #00b8e6 #006699; color:white black"|? <5% 5-20% 20-40% 40-80% 80-100% | ||
|style="width: 14.25%; background:#66e0ff; color:black"|Possible | |style="width: 14.25%; background:#66e0ff; color:black"|Possible | ||
|style="width: 14.25%; background: #E6FAFF; color:black"|Rare | |style="width: 14.25%; background: #E6FAFF; color:black"|Rare |
Revision as of 10:28, 30 April 2023
SUMMARY TABLES
CD13 expression: primitive cell types | ||||||
---|---|---|---|---|---|---|
AML | B ALL | Burkitt | T ALL | ETP ALL (i) | MPAL i | Hgns i |
Limited Rare Possible Likely Frequent Expected | ? <5% 5-20% 20-40% 40-80% 80-100% | Possible | Rare | Likely | Likely | Possible |
Notes: The main application is in AML (see notes for expression). Aberrant expression is seen in ALL - particularly in B-lineage, although it may be less likely in Burkitt lymphoma. CD13 is not generally expressed in T-ALL, but in the correct context CD13 expression can indicate MPAL or ETP-ALL. CD13 is reported to be expressed by some haematognes (click (i) for additional information)
CD13 expression: mature B cell neoplasms* | ||||||
---|---|---|---|---|---|---|
CLL | MCL | FL | MZL | HCL | LPL | PCL |
rare | rare | rare | rare | rare | rare | rare |
Notes: overall expression is uncommon in mature B-lymphoproliferative disorders, but may occur at plasma cell differentiation
CD13 expression: mature T cell neoplasms* | ||||||
---|---|---|---|---|---|---|
ATLL | CTCL/Sezary | T-PLL | T-LGL | NK-LGL | ||
limited | limited | limited | limited | limited |
Notes: There is limited published evidence, but reports suggest expression of CD13 is uncommon in mature T cell malignancy
KEY
1. Colour key: - the likelihood of any individual case expressing this marker, indicated by colour:
There are few reported studies (likely <5%) |
Expression is rare (<5% of cases) |
Expression is seen in some cases (5-20%) |
Expression is likely (20-40% of cases) |
Epression is frequent (40-80%) |
Expect expression in most cases (80-100%) |