CD36: Difference between revisions
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(Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :The main practical use for is in the recognition of megakaryocytic lineage, where expression is expected. However this cell surface receptor has a range of ligands and is expressed on other cells including those of monocyte macrophage lineage so the lineage specificity is not solely for this lineage. </div> :<span style...") |
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:<span style="color:navy">'''Summary'''</span> | :<span style="color:navy">'''Summary'''</span> | ||
:The main practical use for is in the recognition of megakaryocytic lineage | :The main practical use for is in the recognition of megakaryocytic lineage (also called latelet gycoprotein 4) where expression is expected. However this cell surface receptor has a range of ligands and is expressed on other cells including those of monocyte/macrophage and erythrocyte lineage so the lineage specificity is not solely for this lineage. | ||
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:<span style="color:navy">'''Background'''</span> | :<span style="color:navy">'''Background'''</span> | ||
:CD36 is often described as a receptor for thrombospondinn and is involved in platelet adhestion although it also has a wides range of ligand recognition | :CD36 is often described as a receptor for thrombospondinn and is involved in platelet adhestion, although it also has a wides range of ligand recognition | ||
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*A useful additional marker of megakaryocytic lineage proving the reactivity with other cells is recognised | *A useful additional marker of megakaryocytic lineage proving the reactivity with other cells is recognised | ||
*CD36 my also be expressed by cells of monocytic lineage | *CD36 my also be expressed by cells of monocytic and erythrocyte lineages and occasionally granulocytic lineage | ||
*In monocytic differentiation CD36 expression my precede CD14 expression so can be a marker of less differentiated monocytic forms | |||
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Latest revision as of 12:36, 17 October 2023
- Summary
- The main practical use for is in the recognition of megakaryocytic lineage (also called latelet gycoprotein 4) where expression is expected. However this cell surface receptor has a range of ligands and is expressed on other cells including those of monocyte/macrophage and erythrocyte lineage so the lineage specificity is not solely for this lineage.
- Background
- CD36 is often described as a receptor for thrombospondinn and is involved in platelet adhestion, although it also has a wides range of ligand recognition
- Diagnostic Use
- A useful additional marker of megakaryocytic lineage proving the reactivity with other cells is recognised
- CD36 my also be expressed by cells of monocytic and erythrocyte lineages and occasionally granulocytic lineage
- In monocytic differentiation CD36 expression my precede CD14 expression so can be a marker of less differentiated monocytic forms