CD3

Summary

CD3 is a reliable marker of T cell lineage. Loss of expression is rare in T cell malignancies, and aberrant expression by other lineages is very infrequent.

Surface CD3 is acquired during thymic maturation, but is preceded by expression in cytoplams, smaking cytoplasmic CD3 is very useful in the diagnosis of acute T cell leukaemia.

On more mature neoplasms CD3 will be detected on the cell surface.

Normal expression and function

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Diagnostic role

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Other relevant information:

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