CD3: Difference between revisions
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:<span style="color:navy">'''Summary'''</span> | :<span style="color:navy">'''Summary'''</span> | ||
:CD3 is a reliable marker of T cell lineage. Loss of expression is rare in T cell malignancies, and aberrant expression by other lineages is very infrequent. Surface CD3 is acquired during thymic maturation, but is preceded by | :CD3 is a reliable marker of T cell lineage. Loss of expression is rare in T cell malignancies, and aberrant expression by other lineages is very infrequent. | ||
:Surface CD3 is acquired during thymic maturation, but is preceded by expression in cytoplams, smaking cytoplasmic CD3 is very useful in the diagnosis of acute T cell leukaemia. | |||
:On more mature neoplasms CD3 will be detected on the cell surface. | |||
Revision as of 20:54, 30 April 2023
- Summary
- CD3 is a reliable marker of T cell lineage. Loss of expression is rare in T cell malignancies, and aberrant expression by other lineages is very infrequent.
- Surface CD3 is acquired during thymic maturation, but is preceded by expression in cytoplams, smaking cytoplasmic CD3 is very useful in the diagnosis of acute T cell leukaemia.
- On more mature neoplasms CD3 will be detected on the cell surface.
Normal expression and function
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Diagnostic role
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Other relevant information:
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SUMMARY TABLES