CD3: Difference between revisions
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: | :CD3 is a reliable marker of T cell lineage. Loss of expression is rare in T cell malignancies, and aberrant expression by other lineages is very infrequent. Surface CD3 is acquired during thymic maturation, but is preceded by cytoplasmic expression, so presence of cytoplasmic CD3 is very useful in the diagnosis of acute T cell leukaemia. On more mature neoplasms CD3 will be detected on the cell surface. | ||
Revision as of 20:52, 30 April 2023
- Summary
- CD3 is a reliable marker of T cell lineage. Loss of expression is rare in T cell malignancies, and aberrant expression by other lineages is very infrequent. Surface CD3 is acquired during thymic maturation, but is preceded by cytoplasmic expression, so presence of cytoplasmic CD3 is very useful in the diagnosis of acute T cell leukaemia. On more mature neoplasms CD3 will be detected on the cell surface.
Normal expression and function
xxxxx
Diagnostic role
- xxxxx
Other relevant information:
xxxxx
SUMMARY TABLES