CD14

(259, 'cd14', ' cd14 aids recognition ofu800 bacteria byu800 cells ofu800 monocytic lineage. itu800 mayu800 generally beu800 regarded asu800 au800 panu800-monocyte antigen * when expressed inu800 amlu800 cd14 isu800 au800 marker ofu800 monocytic lineage * absence ofu800 cd14 expression does notu800 preclude monocytic lineage since some typical monoblasts dou800 notu800 express this marker * cd14 isu800 notu800 restricted tou800 malignant cells andu800 will beu800 expressed byu800 reactive monocytes andu800 also byu800 neoplastic cells ofu800 cmml normal expression andu800 function together with cou800-receptors cell surface cd14 binds theu800 bacterial cell wall component lipopolysaccharide lpsu800 helping initiate cytokine secretion andu800 theu800 inflammatory response when bacteria areu800 detected. cd14 isu800 anchored tou800 theu800 membrane byu800 au800 glycosylphosphatidylinositol gpiu800 tail attachment mayu800 beu800 cleaved tou800 release au800 soluble form. cd14 isu800 expressed mainly byu800 monocytes dendritic cells andu800 macrophages andu800 tou800 au800 much lower extent byu800 neutrophils . cd14 isu800 weakly expressed oru800 absent onu800 early monocytes butu800 expression becomes progressively stronger asu800 theu800 cells mature. diagnostic role cd14 isu800 au800 useful marker ofu800 monocytic lineage inu800 amlu800. *cases with myelomonocytic lineage will express cd14 onu800 theu800 monocytic population ofu800 blasts *cases with pure monocytic differentiation will generally express cd14 although itu800 mayu800 beu800 absent onu800 less mature monoblasts. *expression isu800 usual onu800 cmml monocytes sou800 itu800 does notu800 distinguish cmml andu800 monocytic amlu800. *expression isu800 very uncommon onu800 lymphoid lineage with 5u800 expression byu800 allu800 cells. other relevant information cd14 isu800 glycophosphoinositol gpiu800 linked andu800 will therefore beu800 absent inu800 cells affected byu800 paraxysmol nocturnal haemoglobinuria pnhu800 . ---- summary tables expression byu800 acute leukaemias andu800 byu800 haematogones file rareu82epngu800 prou800-bu800 allu800 link flow cytometry keyu800 file rareu82epngu800 early preu800-bu800 allu800 link flow cytometry keyu800 file rareu82epngu800 preu800-bu800 allu800 link flow cytometry keyu800 file rareu82epngu800 bu800 allu800 link flow cytometry keyu800 file rareu82epngu800 prou800-tu800 allu800 link flow cytometry keyu800 file rareu82epngu800 mature-tu800 allu800 link flow cytometry keyu800 file frequ82epngu800 amlu800 link flow cytometry keyu800 file rareu82epngu800 haemato-gones link flow cytometry keyu800 notes **inu800 amlu800 cd14 expression defines monocytic lineage restriction butu800 mayu800 beu800 absent especially inu800 more primitive monoblastic cases expression byu800 bu800-lymphoproliferative disorders file rareu82epngu800 frame cllu800 link flow cytometry keyu800 file rareu82epngu800 pllu800 link flow cytometry keyu800 file rareu82epngu800 mclu800 link flow cytometry keyu800 file rareu82epngu800 flu800\' link flow cytometry keyu800 file rareu82epngu800 hclu800 link flow cytometry keyu800 file rareu82epngu800 hclv link flow cytometry keyu800 file rareu82epngu800 mzlu800 link flow cytometry keyu800 file rareu82epngu800 lplu800 link flow cytometry keyu800 file rareu82epngu800 pcsu800 link flow cytometry keyu800 ---- keyu800 theu800 indicated expression frequency indicates theu800 approximate frequency ofu800 occurrence inu800 each particular disease type. file rareu82epngu800 30px link rare 5u800 file possu82epngu800 30px link possible 5u800-20u800 file modu800u82epngu800 30px link likely 20u800-40u800 file frequ82epngu800 30px link frequent 40u800-80u800 file hiu800u82epngu800 30px link expected 80u800 where expression level isu800 unusual oru800 characteristic ofu800 au800 disorder this isu800 indicated byu800 text ---- '),