CD11c

Summary

An adhesion molecule whose expression is confined to leukocytes. High levels of expression are particularly useful in two ontexts:

Contributing to the identifyication of monocytic differentiation in myeloid disorders

Contributing to the idenfification hairy cell leukaemia or related disorders in lymphoid diagnosis, though care must be taken since expression is not fully specific to these disorders.

Normal expression and function

CD11c is an alpha chain of an integrin adhesion receptor that plays an important role in the adhesion of white cells.It is best known as a complement receptor and for aiding monocyte and neutrophil adhesion to endothelium. CD11c is expressed predominantly by myeloid cells, at the highest density on monocytes and myeloid dendritic cells, but also at lower levels on granulocytes. In the lymphoid lineage it is expressed by NK cells and activated T or B lymphocytes.

Diagnostic role

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Other relevant information:

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SUMMARY TABLES

Expression in primitive cell types
AML	B ALL	Burkitt	T ALL	ETP ALL (i)	MPAL i	Hgns i
? <5% 5-20% 20-40% 40-80% 80-100%	? <5% 5-20% 20-40% 40-80% 80-100%	? <5% 5-20% 20-40% 40-80% 80-100%	? <5% 5-20% 20-40% 40-80% 80-100%	? <5% 5-20% 20-40% 40-80% 80-100%	? <5% 5-20% 20-40% 40-80% 80-100%	? <5% 5-20% 20-40% 40-80% 80-100%

Notes: xxxxx

CD13 expression: mature B cell neoplasms
CLL	MCL	FL	MZL	HCL	DLBCL	LPL	PCL
? <5% 5-20% 20-40% 40-80% 80-100%	? <5% 5-20% 20-40% 40-80% 80-100%	? <5% 5-20% 20-40% 40-80% 80-100%	? <5% 5-20% 20-40% 40-80% 80-100%	? <5% 5-20% 20-40% 40-80% 80-100%	? <5% 5-20% 20-40% 40-80% 80-100%	? <5% 5-20% 20-40% 40-80% 80-100%	? <5% 5-20% 20-40% 40-80% 80-100%

Notes: xxxxx

Expression in mature T cell neoplasms*
ATLL	CTCL/Sezary	T-PLL	T-LGL	NK-LGL
? <5% 5-20% 20-40% 40-80% 80-100%	? <5% 5-20% 20-40% 40-80% 80-100%	? <5% 5-20% 20-40% 40-80% 80-100%	? <5% 5-20% 20-40% 40-80% 80-100%	? <5% 5-20% 20-40% 40-80% 80-100%

Notes: xxxxx

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