CD11c: Difference between revisions
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<span style="color:navy">'''Normal expression and function'''</span> | <span style="color:navy">'''Normal expression and function'''</span> | ||
CD11c is an alpha chain of an integrin adhesion receptor that plays an important role in the adhesion of white cells.It is best known as a complement receptor and for aiding monocyte and neutrophil adhesion to endothelium. CD11c is expressed predominantly by myeloid cells, at the highest density on monocytes and myeloid dendritic cells, but also at lower levels on granulocytes. In the lymphoid lineage it is expressed by NK cells and activated T or B lymphocytes. | |||
Revision as of 10:32, 1 May 2023
- Summary
- An adhesion molecule whose expression is confined to leukocytes. High levels of expression are particularly useful in two ontexts:
- Contributing to the identifyication of monocytic differentiation in myeloid disorders
- Contributing to the idenfification hairy cell leukaemia or related disorders in lymphoid diagnosis, though care must be taken since expression is not fully specific to these disorders.
Normal expression and function
CD11c is an alpha chain of an integrin adhesion receptor that plays an important role in the adhesion of white cells.It is best known as a complement receptor and for aiding monocyte and neutrophil adhesion to endothelium. CD11c is expressed predominantly by myeloid cells, at the highest density on monocytes and myeloid dendritic cells, but also at lower levels on granulocytes. In the lymphoid lineage it is expressed by NK cells and activated T or B lymphocytes.
Diagnostic role
- xxxxx
Other relevant information:
xxxxx
SUMMARY TABLES
Expression in primitive cell types | ||||||
---|---|---|---|---|---|---|
AML | B ALL | Burkitt | T ALL | ETP ALL (i) | MPAL i | Hgns i |
? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% |
Notes: xxxxx
CD13 expression: mature B cell neoplasms | |||||||
---|---|---|---|---|---|---|---|
CLL | MCL | FL | MZL | HCL | DLBCL | LPL | PCL |
? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% |
Notes: xxxxx
Expression in mature T cell neoplasms* | ||||||
---|---|---|---|---|---|---|
ATLL | CTCL/Sezary | T-PLL | T-LGL | NK-LGL | ||
? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% |
Notes: xxxxx