CD11c: Difference between revisions
From haematologyetc.co.uk
No edit summary |
No edit summary |
||
Line 5: | Line 5: | ||
:<span style="color:navy">'''Summary'''</span> | :<span style="color:navy">'''Summary'''</span> | ||
: | :An adhesion molecule whose expression is confined to leukocytes. High levels of expression are particularly useful in two ontexts: | ||
:Contributing to the identifying of monocytic differentiation in myeloid disorders | |||
:Contributing to the idenfification hairy cell leukaemia or related disorders in lymphoid diagnosis, though care must be taken since expression is not fully specific to these disorders. | |||
Revision as of 10:28, 1 May 2023
- Summary
- An adhesion molecule whose expression is confined to leukocytes. High levels of expression are particularly useful in two ontexts:
- Contributing to the identifying of monocytic differentiation in myeloid disorders
- Contributing to the idenfification hairy cell leukaemia or related disorders in lymphoid diagnosis, though care must be taken since expression is not fully specific to these disorders.
Normal expression and function
xxxxx
Diagnostic role
- xxxxx
Other relevant information:
xxxxx
SUMMARY TABLES
Expression in primitive cell types | ||||||
---|---|---|---|---|---|---|
AML | B ALL | Burkitt | T ALL | ETP ALL (i) | MPAL i | Hgns i |
? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% |
Notes: xxxxx
CD13 expression: mature B cell neoplasms | |||||||
---|---|---|---|---|---|---|---|
CLL | MCL | FL | MZL | HCL | DLBCL | LPL | PCL |
? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% |
Notes: xxxxx
Expression in mature T cell neoplasms* | ||||||
---|---|---|---|---|---|---|
ATLL | CTCL/Sezary | T-PLL | T-LGL | NK-LGL | ||
? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% |
Notes: xxxxx