Atypical patterns of primitive marker expression in acute myeloid leukaemia: Difference between revisions

Revision as of 13:23, 13 December 2023

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Table: Less frequent patterns of primitive phenotype;
While blast cells typically cause low side scatter of light and have an expression of CD45 that is lower than normal lymphocytes or monocytes, atypical patterns may be encountered. The more frequent patterns are described below.
AML with monocytic differentiation	In AML with monocytic maturation those primitive cells with more mature monocytic features may show higher side scatter (consistent with their size and cytological features) and some or all of the blast cells may also have high expression of CD45 (comparable with normal or CMML monocytes). Such cases may be difficult to distinguish from typical or transforming CMML. It is important to compare with clinical and morphological features to ensure appropriate classification.
Acute promyelocytic leukaemia	Frequently expressed by AML blast cells (40-80% of cases) - most often in less differentiated forms of AML. Expression is also seen frequently (and often more strongly) in ALL
Other patterns	Frequently expressed by AML blast cells (70-80% of cases) - where it can support myeloid differentiation, CD117 also has some value in establishing primitive differentiation as it is lost as cells mature

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 |colspan="1" style = "font-size:90%; color:black;" |'''AML with monocytic differentiation'''
-|colspan="1" style = "font-size:90%;"|In AML with monocytic maturation primitive cells that have significant monocytic maturation may have high side scatter (consistent with their size and cytological features), while some or all of the blast cells may also have high expression of CD45 (comparable with normal or CMML monocytes). Such cases may be difficult to distinguish from typical or transforming CMML. It is important to compare with clinical and morphological features to ensure appropriate classification.
+|colspan="1" style = "font-size:90%;"|In AML with monocytic maturation those primitive cells with more mature monocytic features may show higher side scatter (consistent with their size and cytological features) and some or all of the blast cells may also have high expression of CD45 (comparable with normal or CMML monocytes). Such cases may be difficult to distinguish from typical or transforming CMML. It is important to compare with clinical and morphological features to ensure appropriate classification.
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 |colspan="1" style = "font-size:90%; color:black;" |'''Acute promyelocytic leukaemia'''