Acute leukaemia types: Difference between revisions
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!colspan="4" style = "font-size:90%; background:#DAE8F2"|'''CD45 expression in AML''' | !colspan="4" style = "font-size:90%; background:#DAE8F2"|'''CD45 expression in AML''' | ||
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|colspan="4" style = "font-size: | |colspan="4" style = "font-size:100%; color:black;" |Weak expression of CD45 is "weak" i.e. significantly less intense than normal T cells, B cells or monocytes. The typically low side scatter means that myeloid blast cells tend to form a relatively uniform population on CD45/SSc plots. However, there is some variability releted to indididual subtypes. | ||
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!colspan="3" style = "font-size:90%; background:#DAE8F2"|'''Markers of pimitive cell type expected in AML''' | !colspan="3" style = "font-size:90%; background:#DAE8F2"|'''Markers of pimitive cell type expected in AML''' | ||
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|colspan="1" style = "font-size:90%; color:black;" |'''[[CD34]]''' | |colspan="1" style = "font-size:90%; color:black;" |'''[[CD34]]''' | ||
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|colspan="1" style = "font-size:84%;"|Frequently expressed, most often in less differentiated forms of AML. Expression often less intense than in lymphoid leukaemias | |colspan="1" style = "font-size:84%;"|Frequently expressed, most often in less differentiated forms of AML. Expression often less intense than in lymphoid leukaemias | ||
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|colspan="1" style = "font-size:90%; color:black;" |'''[[CD7]]''' | |colspan="1" style = "font-size:90%; color:black;" |'''[[CD7]]''' | ||
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|colspan="1" style = "font-size:80%;"|Similar to TdT, CD7 expression is recognised on a proportion of AML, usually those with less differentaited phenotype. Most consistently expressed in T-ALL. | |colspan="1" style = "font-size:80%;"|Similar to TdT, CD7 expression is recognised on a proportion of AML, usually those with less differentaited phenotype. Most consistently expressed in T-ALL. | ||
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Revision as of 12:40, 17 July 2023
| Marker patterns in typical acute myeloid leukaemia | |||
|---|---|---|---|
| CD45 expression in AML | |||
| Weak expression of CD45 is "weak" i.e. significantly less intense than normal T cells, B cells or monocytes. The typically low side scatter means that myeloid blast cells tend to form a relatively uniform population on CD45/SSc plots. However, there is some variability releted to indididual subtypes. | |||
| Markers of pimitive cell type expected in AML | |||
| These markers are generally regarded as indicating less differentiated cells, although they have some value in indicating T or B lineage when strogly expressed. | |||
| Marker | Expectation | Comment | |
| CD34 | Frequently expressed, most often in less differentiated forms of AML. Expression often less intense than in lymphoid leukaemias | ||
| TDT | Expressed particularly in less differentiated forms of AML. Often on a sub-population of cells; expression usually less intense than in lymphoid leukaemias | ||
| CD7 | Similar to TdT, CD7 expression is recognised on a proportion of AML, usually those with less differentaited phenotype. Most consistently expressed in T-ALL. | ||