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Revision as of 22:49, 21 December 2023



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What features must be met to diagnose acute undifferentiated leukaemia
Requirement 1
No lineage can be assigned by lineage-defining markers of myeloid, B-lymphoid or T-lymphoid lineage
Requirement 2
No more than one lineage-associated marker for any single lineage is expressed
Requirement 3
Ensure that other conditions that may resemble undifferentiated acute leukaemia are excluded: particularly consider: acute megakaryocytic leukaemia, non haematopoietic tumours, blastic plasma dendritic cell neoplasm, and rarely plasma cell leukaemias.