AUL

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What features must be met to diagnose acute undifferentiated leukaemia This is a difficult area where the diagnosis of acute leukaemia is suspected but no criteria for lineage assignment can be made i.e. the cases do not meet any of the criteria for myeloid, B-lymphoid, or T-lymphoid lineage given above. An important aspect of this group is to exclude the possibility of rare entities that can mimic AML: these include non-haemaotopoietic neoplasm and blastic plasma cell dendritic neoplasm.
Requirement 1
No lineage can be assigned by lineage-defining markers of myeloid, B-lymphoid or T-lymphoid lineage
Requirement 2
No more than one lineage-associated marker for any single lineage is expressed
Requirement 3
Ensure that other conditions that may resemble undifferentiated acute leukaemia are excluded: particularly consider: acute megakaryocytic leukaemia, non haematopoietic tumours, blastic plasma dendritic cell neoplasm, and rarely plasma cell leukaemias.