Test: Difference between revisions

Revision as of 16:02, 13 July 2023

Background to flow cytometric diagnosis

These cells share features of mature B cell differentation with features of early plasma cell differentiation and may have mixed populations with features of each. Where either B-cell differentiation or plasma cell features predominate this can make the diagnosis difficult.

Immunophenotype of DLBCL
Major markers useful in CLL diagnosis
Marker	Freq	Level	Comment
CD19		-	Generally CD19 will be expressed
κ/λ			Light chain retriction usually detected
CD5		-	Uncommon but seen in some cases
CD23		-	Infrequent but reported
CD79b		-	Generally expressed
CD200		-	Detected infrequently
FMC7			Generally expressed
Other relevant markers
CD10		-	Expression may be seen
CD11C		-
CD20		-	Expect expression
CD25		-
CD38		-
CD43		-
CD103		-
CD138		-

Key to table:

Key to colour code for expression frequency Click for link

Key to expression strength code and use Click for link

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-[[file:DLBCL.jpg|200px|link=BLBCL.jpg]]
+[[file:LPL.jpg|200px|link=LPL.jpg]]
 <span style="color: navy>'''Background to flow cytometric diagnosis'''</span>
-This is an uncommon diagnosis by flow cytometry and the immunophenotype is less frequently reported. This table represents the most frequet penotypic features, but emphasises that there is no absolutely typical pattern that sets this diagnosis apart from other B-LPD. However, DLBCL cells generally circulate and involve bone marrow only at only a late stage in disease so in many cases a diagnosis has already been made. Where these cases present as a new diagnosis by blood or marrow diagnosis requires careful correllation with other features.
+These cells share features of mature B cell differentation with features of early plasma cell differentiation and may have mixed populations with features of each. Where either B-cell differentiation or plasma cell features predominate this can make the diagnosis difficult.

Test: Difference between revisions

From haematologyetc.co.uk

Revision as of 16:02, 13 July 2023