Actions

Special

New pages

New pages
Hide registered users | Hide bots | Show redirects
  • 10:56, 26 March 2024Schizont Development (hist | edit) ‎[4,314 bytes]Admin (talk | contribs) (Created page with "---- '''Navigation'''</br> Go Back ---- {| class="wikitable" style="border-style: solid; border-width: 4px; color:black" |colspan="1" style = "font-size:100%; color:black; background: FFFAFA"|<span style="color:navy>'''How is red cell size and shape affected as malaria develops?'''</span> During parasite develop,emt each species alters the red cell that they occupy. These changes differ between species causing characteristic chan...")
  • 21:15, 24 March 2024Red cell size and shape (hist | edit) ‎[3,463 bytes]Admin (talk | contribs) (Created page with "---- '''Navigation'''</br> Go Back ---- {| class="wikitable" style="border-style: solid; border-width: 4px; color:black" |colspan="1" style = "font-size:100%; color:black; background: FFFAFA"|<span style="color:navy>'''How is red cell size and shape affected as malaria develops?'''</span> During parasite develop,emt each species alters the red cell that they occupy. These changes differ between species causing characteristic chan...")
  • 20:31, 23 March 2024Red cell size (hist | edit) ‎[3,327 bytes]John (talk | contribs) (Created page with "red. cell size description characteristic changes to. red. cell size and. shape occur during parasite development from a. relatively early stage of. parasite development the. very earliest trophozoites may. not. show these features * p..emalariae red. cells remain round and. are. often small in. size * p..efalciparum red. cells unchanged in. size may. become crenated * p..eovale red. cells generally become enlarged and. ovoid may. become fimbriated * p..evivax...")
  • 20:27, 23 March 2024Maurer's dots and clefts (hist | edit) ‎[1,968 bytes]John (talk | contribs) (Created page with "Maurer maurer's dots and clefts Description: These are blue-grey dots or linear structures contained within erythrocytes infected by the late trophozoites of P.falciparum and represent modification of the red cell by the parasite. The structures differ from the dot in p.vivax or p.ovale since they are few in number you could imagine being able to count them (in the unlikely case that you wanted to). They are not seen in early trophozoites. Species significance: T...")
  • 20:26, 23 March 2024Stained correctly (hist | edit) ‎[1,331 bytes]John (talk | contribs) (Created page with "description staining: more alkaline than normal films is recommended for malaria parasite evaluation - irrespective of colour preference this makes parasites more visible compared with the grey of the surrounding red cells and makes some structures such as cytoplasmic dots more visible.")
  • 23:37, 20 March 2024P.falciparum gametocyte gallery (hist | edit) ‎[1,866 bytes]Admin (talk | contribs) (Created page with "---- '''Navigation'''</br> Go Back ---- {| class="wikitable" style="border-style: solid; border-width: 4px; color:black" |colspan="1" style = "font-size:100%; color:black; background: FFFAFA"|<span style="color:black> {| class="wikitable" style="border-style: solid; border-width: 0px; border-color: #023020; color:black" |colspan="1" style = "font-size:100%; color:black; background: CBD5CO |'''''P.falciparum'' gallery of late trophoz...")
  • 23:34, 20 March 2024P.falciparum schizont gallery (hist | edit) ‎[1,689 bytes]Admin (talk | contribs) (Created page with "---- '''Navigation'''</br> Go Back ---- {| class="wikitable" style="border-style: solid; border-width: 4px; color:black" |colspan="1" style = "font-size:100%; color:black; background: FFFAFA"|<span style="color:black> {| class="wikitable" style="border-style: solid; border-width: 0px; border-color: #023020; color:black" |colspan="1" style = "font-size:100%; color:black; background: CBD5CO |'''''P.falciparum'' gallery of late trophoz...")
  • 23:15, 20 March 2024P.falciparum late trophozoites gallery (hist | edit) ‎[1,788 bytes]Admin (talk | contribs) (Created page with "---- '''Navigation'''</br> Go Back ---- {| class="wikitable" style="border-style: solid; border-width: 4px; color:black" |colspan="1" style = "font-size:100%; color:black; background: FFFAFA"|<span style="color:black> {| class="wikitable" style="border-style: solid; border-width: 0px; border-color: #023020; color:black" |colspan="1" style = "font-size:100%; color:black; background: CBD5CO |'''''P.falciparum'' gallery of early tropho...")
  • 15:23, 19 March 2024Malaria stage recognition (hist | edit) ‎[590 bytes]Admin (talk | contribs) (Created page with "{| class="wikitable" style="border-style: solid; border-width: 5px; border-color: #023020; color:black" |colspan="1" style = "font-size:100%; color:black; background: CBD5CO |'''Geographical distribution''' |} ''P.falciparum'' infection occurs in tropical and subtropical areas of central and South America, Africa, and S.E.Asia; this resembles the distribution of ''P.malariae'' and overlaps but is distinct from the distribution of ''P.vivax'' and ''P.ovale''. Detailed...")
  • 19:38, 17 March 2024Species identification: summary page (hist | edit) ‎[6,560 bytes]Admin (talk | contribs) (Created page with "Return to Malaria Index Page'' ---- {| class="wikitable" style="border-style: solid; border-width: 5px; border-color: #bcd4e6; color:black" |colspan="1" style = "font-size:90%; color:black; background: #bcd4e6"|'''''Plasmodium falciparum''''' |} <span style="font-size:95%">'''Summary'''</span> *<span style="font-size:95%">Small and fine ring forms, may have accolé (edge) forms or multiple parasites per cell</span> *<span style="font-size:95%">Mau...")
  • 10:20, 15 March 2024Accolé form (hist | edit) ‎[1,741 bytes]John (talk | contribs) (Created page with "---- '''Description''' Accolé forms may also be referred to as "edge" or “appliqué” form, and describes parasites in early or late trophozoites where the parasite appears closely opposed to the edge of the erythrocyte membrane - usually appearing to be flattened against the erythrocyte membrane. IMAGE '''Species significance''' Most often considered to be a feature of p.falciparum infection and can be helpful to indicate this diagnosis (particularly when freq...")
  • 10:13, 15 March 2024Multiple parasites (hist | edit) ‎[1,656 bytes]John (talk | contribs) (Created page with "'''Description''' In some cases more than one early or late trophozoite may infect a single erythrocyte, the two are visible as entirely separate parasites. MAIN IMAGE '''Species significance ''' Most often considered a feature indicating ''P.falciparum'' infection, and is certainly frequent in this species (helping support) the diagnosis. The form should not however be considered as specific, and may occur in any species (and is also frequent for the ring forms o...")
  • 10:08, 15 March 2024Double chromatin dot forms (hist | edit) ‎[1,498 bytes]John (talk | contribs) (Created page with "'''Description''' Early or late trophozoites where the chromatin dot has two separate masses - a double dot that is sometimes said to resemble a signet ring, although this really only applies for typical ring forms where dots are relatively close together. IMAGE 1 '''Species significance''' Most often this appearance is considered to be a feature of ''P.falciparum'' and can be helpful to indicate this species; however the form is not specific and may occur in an...")
  • 11:48, 14 March 2024Plasmodium falciparum: Morphology (hist | edit) ‎[5,336 bytes]Admin (talk | contribs) (Created page with " ---- '''Geographical distribution''' ''P.falciparum'' infection occurs in tropical and subtropical areas of central and South America, Africa, and S.E.Asia; this resembles the distribution of ''P.malariae'' and overlaps but is distinct from the distribution of ''P.vivax'' and ''P.ovale''. Detailed geographical information may be accessed here: [https://malariaatlas.org/explorer/#/]. ---- '''The early trophozoite''' <gallery mode="nolines" widths=200px heights=2...")
  • 11:45, 14 March 2024P.falciparum early trophozoites gallery (hist | edit) ‎[1,730 bytes]Admin (talk | contribs) (Created page with "---- <div style="width: 240px"> {| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black; font-size:90%; color:navy" | colspan="1"''|Return to Species Menu'' |} </div> ---- ''' ''P.falciparum'' early trophozoites '''</br> <span style="font-size:95%">'''Summary'''</span> <span style="font-size:95%">At this stage we look for typical (and often frequent) delicate ring...")
  • 10:09, 13 March 2024Trophozoites: diagnostic guide (hist | edit) ‎[3,404 bytes]Admin (talk | contribs) (Created page with "''' ''P.falciparum'' ''' <gallery mode="nolines" widths="220px" heights="220px" > File:MFETr.jpg|link={{filepath:MFETr.jpg}} File:MFITr.jpg|link={{filepath:MFITr.jpg}} File:MFLTr.jpg|link={{filepath:MFLTr.jpg}} </gallery> ''Small and often delicate rings that thicken at later developmental stages although they remain relatively small with a "ring appearance". Note that the red cell size is unchaged and not distorted, also the appearance of characteristic Maurer's dots...")
  • 12:54, 26 February 2024''Plasmodium falciparum'': Morphology (hist | edit) ‎[3,208 bytes]John (talk | contribs) (Created page with " ---- '''Geographical distribution''' ''P.falciparum'' infection occurs in tropical and subtropical areas of central and South America, Africa, and S.E.Asia; this resembles the distribution of ''P.malariae'' and overlaps but is distinct from the distribution of ''P.vivax'' and ''P.ovale''. Detailed geographical information may be accessed here: [https://malariaatlas.org/explorer/#/]. ---- '''The early trophozoite''' File:PFET.jpg|left|220px|link={{filepath:PFE...")
  • 12:43, 22 February 2024''P.falciparum'' gallery (hist | edit) ‎[1,550 bytes]John (talk | contribs) (Created page with "<gallery mode="nolines" widths=150px heights=150px> File:PFETc.jpg|<span style="font-size:80%">''Early trophozoite''</span>|link={{filepath:PFETc.jpg}} File:PFLTc.jpg|<span style="font-size:80%">Late trophozoite</span>|link={{filepath:PFLTc.jpg}} File:PFGc.jpg|<span style="font-size:80%">Gametocyte</span>|link={{filepath:PFGc.jpg}} </gallery>")
  • 11:51, 31 January 2024Marker patterns erythroid or megakaryocyte differentiation (hist | edit) ‎[4,904 bytes]John (talk | contribs) (Created page with "---- <div style="width: 200px"> {| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black; font-size:90%; color:navy" | colspan="1"''|Return to previous page'' |} </div> ---- <span style="font-size:90%>'''Acute erythroid leukaemia (AEL)'''</br>This may be a difficult diagnosis since markers will often not allow cells to be distinguished from a re...")
  • 18:24, 30 January 2024Marker patterns of other AML-related differentiation (hist | edit) ‎[4,558 bytes]John (talk | contribs) (Created page with "---- <div style="width: 200px"> {| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black; font-size:90%; color:navy" | colspan="1"''|Return to previous page'' |} </div> ---- ''These markers are not considered to define myeloid lineage, and generally have lower lineage specificity than myeloid-lineage associated markers, however they can support c...")
  • 18:53, 13 January 2024Flow cytometry: Myeloid-defining markers (hist | edit) ‎[4,340 bytes]John (talk | contribs) (Created page with "---- <div style="width: 200px"> {| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black; font-size:90%; color:navy" | colspan="1"''|Return to previous page'' |} </div> ---- <span style="font-size:90%;>To assign myeloid lineage in MPAL, only lineage-defining charateristics should be considered.</span> <div style="width: 100%; border: 1px solid black; font-size:1...")
  • 18:50, 13 January 2024Flow cytometry: Myeoid-defining markers (hist | edit) ‎[0 bytes]John (talk | contribs) (Created page with "---- <div style="width: 200px"> {| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black; font-size:90%; color:navy" | colspan="1"''|Return to previous page'' |} </div> ---- <span style="font-size:90%;>To assign myeloid lineage in MPAL, only lineage-defining charateristics should be considered.</span> <div style="width: 100%; border: 1px solid black; font-size:1...")
  • 13:11, 12 January 2024Table of frequent aberrant markers in AML (hist | edit) ‎[1,552 bytes]John (talk | contribs) (Created page with "It is well recognised that marker expression in acute myeloid leukaemia may frequently include the expression of immunological markers not typically associated with myeloid lineage. Broadly, the abberant expression may include: Markers of primitive phenotype that are more frequently associated with lymphoid disorders, most frequently, CD7 43% BCRABL TdT 7% Markers associated with lymphoid maturation that may also be expressed by the lineage maturation, particularly mon...")
  • 23:13, 11 January 2024Recognition of APL differentiation (hist | edit) ‎[1,240 bytes]John (talk | contribs) (Created page with " <div id="AML_AplPic">'''Recognition of acute promyelocytic leukaemia'''</div> 130px <span style="font-size:90%">Typical APL has cells that are hypergranular (A) or may be the microgranular variant (B) generally the cells will have a range of granulation or nuclear appearance. While CD45 expression tends to be weak, in almost all cases the variable morphological features cause a wide range of side-scatter with the abnormal cells often forming a...")
  • 23:10, 11 January 2024Recognition of blast cells with monocytic differentiation (hist | edit) ‎[1,635 bytes]John (talk | contribs) (Created page with "---- <div id="AML_MonoPic">'''Recognition of blast cells with monocytic differentiation'''</div> 130px|caption '''A''' monoblastic AML 130px|caption '''B''' monocytic AML <span style="font-size:90%"> *'''Panel A''': Where cells have a monoblastic differentiation (generally large blast cells with primitive chromatin and nucleoli that lack ''monocytic shape'' often with basophilic cytoplasm) the monoblasts tend to express marke...")
  • 14:28, 9 January 2024Flow Cytometry:T-Lymphoid lineage assignment in MPAL (hist | edit) ‎[4,352 bytes]John (talk | contribs) (Created page with "---- <div style="width: 200px"> {| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black; font-size:90%; color:navy" | colspan="1"''|Return to previous page'' |} </div> ---- <div style="width: 95%"> {| class="wikitable" style="border-style: solid; border-width: 5px; color:black" |colspan="1" style = "font-size:90%; color:black; background:#bcd4e6"|'''Mixed Pheno...")
  • 11:47, 9 January 2024Flow Cytometry:B-lymphoid lineage assignment in MPAL (hist | edit) ‎[3,047 bytes]John (talk | contribs) (Created page with "---- <div style="width: 200px"> {| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black; font-size:90%; color:navy" | colspan="1"''|Return to previous page'' |} </div> ---- <div style="width: 95%; border: 1px solid black; font-size:100%"> {| class="wikitable" style="color:black; background-color:#ffffff;" cellpadding="0" !colspan="2" <span style="font-size:90%...")
  • 11:42, 9 January 2024Flow Cytometry:Myeloid lineage assignment in MPAL (hist | edit) ‎[4,323 bytes]John (talk | contribs) (Created page with "---- <div style="width: 200px"> {| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black; font-size:90%; color:navy" | colspan="1"''|Return to previous page'' |} </div> ---- <div style="width: 100%; border: 1px solid black; font-size:100%"> {| class="wikitable" style="color:black; background-color:#ffffff;" cellpadding="0" !colspan="2" <span style="font-size:90...")
  • 12:20, 5 January 2024Tables of diagnostic patterns associated with aberrancy or alternative diagnosis in AML (hist | edit) ‎[722 bytes]John (talk | contribs) (Created page with "---- <div style="width: 200px"> {| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black; font-size:90%; color:navy" | colspan="1"''|Return to previous page'' |} </div> --------")
  • 12:13, 5 January 2024Tables of diagnostic markers supporting assignment of primitive phenotype in AML (hist | edit) ‎[543 bytes]John (talk | contribs) (Created page with "Markers used to demonstrate primitive nature in AML Atypical patterns of primitive marker expression in acute myeloid leukaemia")
  • 11:50, 5 January 2024Tables of diagnostic markers supporting lineage assignment in AML (hist | edit) ‎[1,175 bytes]John (talk | contribs) (Created page with " Myeloid lineage-defining markers")
  • 12:23, 4 January 2024Flow cytometry:ETP-ALL (hist | edit) ‎[3,179 bytes]John (talk | contribs) (Created page with "---- <div style="width: 200px"> {| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black; font-size:90%; color:navy" | colspan="1"''|Return to previous page'' |} </div> -------- <div style="width: 95%"> {| class="wikitable" style="border-style: solid; border-width: 5px; color:black" |colspan="1" style = "font-size:90%; color:black; background:#ddeee1"|'''1. The primi...")
  • 11:59, 4 January 2024ETP-ALL (hist | edit) ‎[1,849 bytes]John (talk | contribs) (Created page with "ETPs are recent immigrants from the bone marrow (BM) to the thymus, derived from hematopoietic stem cells, which retain a certain level of multilineage pluripotency.7,8 By gene expression profiling, ETP cells share similarities with hematopoietic stem cells and myeloid progenitor cells.5 The definition of ETP-ALL/LBL is based on the immunophenotype of the leukemic cells, which are typically CD1a−, CD8−, CD5− (dim), and positive for 1 or more stem cell or myeloid...")
  • 13:02, 2 January 2024Flow cytometry:BPDCN (hist | edit) ‎[2,957 bytes]John (talk | contribs) (Created page with "---- <div style="width: 200px"> {| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black; font-size:90%; color:navy" | colspan="1"''|Return to previous page'' |} </div> ---- <div style="width: 95%"> {| class="wikitable" style="border-style: solid; border-width: 5px; color:black" |colspan="1" style = "font-size:90%; color:black; background:#ddeee...")
  • 14:11, 31 December 2023Flow cytometry:ALAL-NOS (hist | edit) ‎[779 bytes]John (talk | contribs) (Created page with "---- <div style="width: 200px"> {| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black; font-size:90%; color:navy" | colspan="1"''|Return to previous page'' |} </div> ---- Reserved for cases where a primitive haematopoietic malignancy is established but where confident assignment to any specific category is not possible. This diagnosis is rar...")