Schizont Development

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How does schizont appearance change during their development? Schizonts formation involves successive cycles of asexual division that eventually result in the formation of multiple separate "merozoite" forms. Those merozoites are released as the red cell breaks down then go on to infect another red cell. Schizonts therefre look very different depending on which stage of development they represent. Below are images of schizonts at different developmental stages. THE INITIAL ASEXUAL DIVISION The first recognisable stage occurs when the schizonts first divide their chromatin to form two distinct masses. This first stage is the least distinctive and can be difficult to distinguish from a late trophozoite or gametocyte with a double chromatin dot. But often the appearance is clear. A B The cartoon image (A) shows the division of chromatin into two masses within a continuous blue parasite cytoplasm (indiviual merozoites are not really distinguishable here). A clinical image of a parasite at this developmental stage (P.ovale with well shown James'dots) is shown in panel (B). IMMATURE SCHIZONT APPEARANCES As schizont development proceeds further cycles of division cause the appearance of mutiple separate areas chromatin that will eventually form the merozoies, although at this stage they still lie within a single cytoplasmic mass. The number of divisions varies between species, so in mature schizonts this can contribute to species identification (see schizont gallery). Note that as the parasites develop the haemoglobin is metabolised so the red cell becomes more pale, and the products of red cell breakdown (malaria pigment) become more prominent. A B The cartoon image (A) shows the further division of chromatin (Chr) into many discrete massed within the blue parasite cytoplasm (Cy). Indiviual merozoites are still not distinguishable but the malaria pigment is obvious (Pi). A clinical image of a parasite at this developmental stage (again from P.ovale with well shown James'dots and malaria pigment) is shown in panel (B). MATURE SCHIZONT APPEARANCES xxxxxx A B xxxxxx. MEROZOITE RELEASE xxxxxx A B xxxxxx.