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Schüffner's dots: Difference between revisions

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<span style="font-size:80%">The most frequent form - two early trophozoites of ''P.falciparum'' in a single erythrocyte</span>
 
<span style="font-size:100%">Well formed Schüffner's dots in a trophozoite of ''P.vivax''; note that the dots are far too numerous to count and have a red/purple colour; remeber also that their appearance is highly dependent on the correct staining pH.</span>
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<span style="color:navy>'''Species significance'''</span>   
<span style="color:navy>'''Species significance'''</span>   


Most often considered a feature indicating ''P.falciparum'' infection, and is certainly frequent in that species where it can be used to support the diagnosis. However, the form should not considered as specific, and may occur in any species (and is also a frequent finding for babesia parasites).
These dots are a feature of ''P.vivax'', but are morphologically indistinguishable from the James dots of ''P.ovale''. Distinction between these species must therefore be made based on other diagnostic crieria.  
 


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<span style="font-size:80%">Double parasites in: late trophozoite of ''P.malaria'' (A) late trophozoite of ''P.vivax'' (B) and late trophozoite of P.ovale (C)</span>
<span style="font-size:100%">The appearance of Schüffner's dots during the develoment of ''P.vivax'' trophozites. These are shown from their earliest detectable form in an early trophozoite that has also begun to increase the size and distort the erythrocyte (A), these are more fully developed at later stages (B) and are highly visible in the amoeboid late trophozoite (C). </span>
 
 
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|colspan="1" style = "font-size:100%; color:black; background: FFFAFA"|<span style="color:navy>'''What are Schüffner's dots?'''</span>
 
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<span style="color:navy>'''Description'''</span>
 
 
These are frequent red-purple dots in the erythrocyte cytoplasm of cells infected by ''P.vivax'' (like the James' dots seen in ''P.ovale'') that develop from early trophozoite infection as faint dots, then become more obvious in all mature forms. These represent modification of the red cell by the parasite''. initially appearing as very faint dots before becoming much more intense as the parasites become more mature. Different intensities of cytoplasmic dots, from faint to intense during the development of ''P.vivax''. Note that even when faint dots are very frequent (compare with the sparse Maurer's dots and clefts of ''P.falciparum'')
 
 
 
 
<span style="color:navy>'''Species significance'''</span>
 
 
These dots are restricted to ''P.ovale'' (but are indistinguishable from the Schüffner's dots of ''P.vivax)''. Note the appearance of dots is highly dependent on correct staining pH.
 
 
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Latest revision as of 13:44, 3 April 2024


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What are Schüffner's dots?

Schüffner's dots are red-purple dots seen in P.vivax. They are morphologically indistinguishable from the James' dots of P.ovale but are very diffrent from the more dense and blue coloured Maurer's dots and clefts of P.falciparum. Like all parasite structures Schüffner's dots form progressively, and may not be seen in very early trophozoites.


Well formed Schüffner's dots in a trophozoite of P.vivax; note that the dots are far too numerous to count and have a red/purple colour; remeber also that their appearance is highly dependent on the correct staining pH.


Species significance

These dots are a feature of P.vivax, but are morphologically indistinguishable from the James dots of P.ovale. Distinction between these species must therefore be made based on other diagnostic crieria.



Additional images

The appearance of Schüffner's dots during the develoment of P.vivax trophozites. These are shown from their earliest detectable form in an early trophozoite that has also begun to increase the size and distort the erythrocyte (A), these are more fully developed at later stages (B) and are highly visible in the amoeboid late trophozoite (C).