View source for Additional immunophenotypic markers useful in lineage assignment or subtyping of AML

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''These markers are not considered to define myeloid lineage, and generally have lower lineage specificity than myeloid-lineage associated markers, however they can support classification or support lineage assignment in difficult cases''</br></br>
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!colspan="2" <span style="font-size:100%; colour:white; text-align:left; border: 1px solid black; background:lightgrey">|'''Markers that may be used to support granulocytic or monocytic maturation in AML'''</span><span style="font-size:90%; text-align:left; background:white">
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|colspan="2" style = "font-size:90%; color:black; background:#ddeee1" |These may be less specific than other markers but can be a useful adjunct in difficult cases
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|colspan="1" style = "font-size:90%; color:black;" |'''[[CD11b]]'''
|colspan="1" style = "font-size:84%;"|A marker of both granulocytic and monocytic maturation, this marker has previously been associated with less good outcome in a number of studies
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|colspan="1" style = "font-size:90%; color:black;" |'''[[CD11c]]'''
|colspan="1" style = "font-size:84%;"|This marker is most associated with monocytic maturation in AML being fairly well corellated with CD11B, but overall probably less specific for monocytic differentiation that CD14
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!colspan="2" <span style="font-size:100%; colour:white; text-align:left; border: 1px solid black; background:lightgrey">|'''Markers associated with erythroid differentiation in AML'''</span><span style="font-size:90%; text-align:left; background:white">
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|colspan="2" style = "font-size:90%; color:black; background:#ddeee1" |Most often AML with erythroid maturation will express [[CD34]], while [[CD45]] and [[HLA-DR]] are weak or negative. [[CD117]] is generally expressed. There may be some expression of megkaryocytic markers in some cases.
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|colspan="1" style = "font-size:90%; color:black;" |'''[[CD36]]'''
|colspan="1" style = "font-size:84%;"|Expression is expected, but often expressed in other subtypes so not fully lineage specific
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|colspan="1" style = "font-size:90%; color:black;" |'''[[CD71]]'''
|colspan="1" style = "font-size:84%;"|Frequently expressed though not fully lineage specific
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|colspan="1" style = "font-size:90%; color:black;" |'''[[CD235]]'''
|colspan="1" style = "font-size:84%;"|A good marker of erythroid differentiation but acquired late and therefore may not be expressed
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!colspan="2" <span style="font-size:100%; colour:white; text-align:left; border: 1px solid black; background:lightgrey">|'''Markers associated with megakaryocytic differentiation in AML'''</span><span style="font-size:90%; text-align:left; background:white">
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|colspan="2" style = "font-size:90%; color:black; background:#ddeee1" |Most often [[CD34]], [[CD45]] and [[HLA-DR]] are weak or negative, although [[CD13]] and [[CD33]] may be expressed
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|colspan="1" style = "font-size:90%; color:black;" |'''[[CD41]]'''
|colspan="1" style = "font-size:84%;"|Platelet glycoprotein IIbIIIa
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|colspan="1" style = "font-size:90%; color:black;" |'''[[CD61]]'''
|colspan="1" style = "font-size:84%;"|Platelet glycoprotein IIIa
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|colspan="1" style = "font-size:90%; color:black;" |'''[[CD36]]'''
|colspan="1" style = "font-size:84%;"|Relatively non-specific (seen in erythroid and monocytic leukaemias) but often strongly expressed
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!colspan="2" <span style="font-size:100%; colour:white; text-align:left; border: 1px solid black; background:lightgrey">|'''Markers associated with basophilic differentiation in AML'''</span><span style="font-size:90%; text-align:left; background:white">
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|colspan="1" style = "font-size:90%; color:black;" |'''[[CD22]]'''
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|colspan="1" style = "font-size:90%; color:black;" |'''[[CD123]]'''
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|colspan="1" style = "font-size:90%; color:black;" |'''[[CD203]]'''
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|colspan="1" style = "font-size:90%; color:black;" |'''[[CD11b]]'''
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