TCRαβ - Revision history

John at 19:27, 14 May 2023

2023-05-14T19:27:31Z

← Older revision		Revision as of 21:27, 14 May 2023
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	:<span style="color:navy">'''Summary'''</span>		:<span style="color:navy">'''Summary'''</span>

	:In the ~~detection~~ of ~~haematological malignancy the purpose of detecting γδ~~ T cells ~~is to define particular T cell lymphomas (αβ T cells strongly predominate in normal blood)~~. ~~However care must be taken when small populations~~ of ~~γδ T cells are detected however, since these~~ may ~~arise in response to viral~~ or ~~other immune responses.~~		:The αβ TCR is the primary form in health accounting for around 95% of circulating T cells. Alteration of that normal expression pattern may suggest a neoplastic or inflammatory disorder


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	:<span style="color:navy">'''Background'''</span>		:<span style="color:navy">'''Background'''</span>

	:T cell receptor (TCR) ~~analysis in blood is not generally helpful in indicating T~~-~~cell clonality since around 95% express~~ of ~~circulating~~ T cells ~~express αβ chains and only 5% have gamma γδ. In tissues~~ this ~~can be different since the γδ T cells~~ are ~~more abundant in skin and intraepithelial areas. The receptors also have different functions:~~ αβ T ~~cells behave as elements of the adaptive immune system while γδ cells have an innate immune function similar to NK~~ cells.		:The αβ chains expressed are expressed as part of the T-cell receptor (TCR) complex - these are the antigen recognising parts of the complex. T cells expressing this receptor are referred to as αβ T cells.


	:<span style="color:navy">'''Diagnostic Use'''</span>		:<span style="color:navy">'''Diagnostic Use'''</span>

	*~~A predominant population of~~ γδ ~~T cells circulate~~ may ~~indicate~~ a ~~clonal proliferation most commonly will be hepatosplenic gamma-delta T-cell lymphoma or primary cutaneous t cell~~ lymphoma ~~(PTCL)~~		*Significant populations expressing gd chains may indicate autoimmune or inflammaotory disease
	*~~Disturbance of the ratio~~ of αβ/γδ ~~may be seen~~ in ~~reactive conditions~~		*γδ restriction or predominance may suggest a γδ lymphoma
			*Absence of αβ or γδ is found in NK lineage disorders



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John at 09:49, 14 May 2023

2023-05-14T09:49:41Z

← Older revision		Revision as of 11:49, 14 May 2023
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	*A predominant population of γδ T cells circulate may indicate a clonal proliferation most commonly will be hepatosplenic gamma-delta T-cell lymphoma or primary cutaneous t cell lymphoma (PTCL)		*A predominant population of γδ T cells circulate may indicate a clonal proliferation most commonly will be hepatosplenic gamma-delta T-cell lymphoma or primary cutaneous t cell lymphoma (PTCL)
	*Disturbance of the ~~ration~~ of αβ/γδ may be seen in reactive conditions		*Disturbance of the ratio of αβ/γδ may be seen in reactive conditions


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John at 09:49, 14 May 2023

2023-05-14T09:49:19Z

← Older revision		Revision as of 11:49, 14 May 2023
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	*A predominant population of γδ T cells circulate may indicate a clonal proliferation most commonly will be hepatosplenic gamma-delta T-cell lymphoma or primary cutaneous t cell lymphoma (PTCL)		*A predominant population of γδ T cells circulate may indicate a clonal proliferation most commonly will be hepatosplenic gamma-delta T-cell lymphoma or primary cutaneous t cell lymphoma (PTCL)
			*Disturbance of the ration of αβ/γδ may be seen in reactive conditions


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John: Created page with "
:'''Summary''' :In the detection of haematological malignancy the purpose of detecting γδ T cells is to define particular T cell lymphomas (αβ T cells strongly predominate in normal blood). However care must be taken when small populations of γδ T cells are detected however, since these may arise in response to viral or other immune r..."

2023-05-14T09:48:01Z

Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :In the detection of haematological malignancy the purpose of detecting γδ T cells is to define particular T cell lymphomas (αβ T cells strongly predominate in normal blood). However care must be taken when small populations of γδ T cells are detected however, since these may arise in response to viral or other immune r..."

New page

<div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;">

:<span style="color:navy">'''Summary'''</span>

:In the detection of haematological malignancy the purpose of detecting γδ T cells is to define particular T cell lymphomas (αβ T cells strongly predominate in normal blood). However care must be taken when small populations of γδ T cells are detected however, since these may arise in response to viral or other immune responses.

</div>

:<span style="color:navy">'''Background'''</span>

:T cell receptor (TCR) analysis in blood is not generally helpful in indicating T-cell clonality since around 95% express of circulating T cells express αβ chains and only 5% have gamma γδ. In tissues this can be different since the γδ T cells are more abundant in skin and intraepithelial areas. The receptors also have different functions: αβ T cells behave as elements of the adaptive immune system while γδ cells have an innate immune function similar to NK cells.

:<span style="color:navy">'''Diagnostic Use'''</span>

*A predominant population of γδ T cells circulate may indicate a clonal proliferation most commonly will be hepatosplenic gamma-delta T-cell lymphoma or primary cutaneous t cell lymphoma (PTCL)

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