Nucleated Red Cells (nRBC) - Revision history

John at 17:34, 24 March 2023

2023-03-24T17:34:41Z

← Older revision		Revision as of 19:34, 24 March 2023
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	<gallery mode="nolines" widths="240px" heights="240px" border="1px" >		<gallery mode="nolines" widths="240px" heights="240px" border="1px" >
	File:~~Nrbc1A~~.png\|link={{filepath:Nrbc1.png}}		File:NRBC1A.png\|link={{filepath:Nrbc1.png}}
	File:Nrbc 2.jpg\|link={{filepath:Nrbc 2.jpg}}		File:Nrbc 2.jpg\|link={{filepath:Nrbc 2.jpg}}
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John at 17:33, 24 March 2023

2023-03-24T17:33:52Z

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John at 10:30, 21 March 2023

2023-03-21T10:30:51Z

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John at 10:29, 21 March 2023

2023-03-21T10:29:03Z

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John at 10:28, 21 March 2023

2023-03-21T10:28:24Z

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	File:Nrbc1.png\|link={{filepath:Nrbc1.png}}		File:Nrbc1.png\|link={{filepath:Nrbc1.png}}
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John at 10:27, 21 March 2023

2023-03-21T10:27:10Z

← Older revision		Revision as of 12:27, 21 March 2023
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	<span style="font-style:italic; font-size:90%;'' >		<span style="font-style:italic; font-size:90%;'' >
	'''Appearance''' Individual nucleated red cells. These are difficult cells to illustrate with a single image since the size, and appearance of both cytoplasm and nucleus vary with cell maturity – recognition generally depends on identifying typical cytoplasmic appearance (a varying red hue that depends on the amount of haemoglobin and developmental stage) and the typically round and dense nucleus of later stages. Often the cause of the circulating nucleated forms will be shown by the accompanying cells – in the ~~cartoon~~ example ~~there is a sickle cell~~ there is a teardrop form as well as a polychromatic cell (note the very similar cytoplasmic colour to the nucleated cell). The clinical examples also shows misshapen red cells and polychromasia.		'''Appearance''' Individual nucleated red cells. These are difficult cells to illustrate with a single image since the size, and appearance of both cytoplasm and nucleus vary with cell maturity – recognition generally depends on identifying typical cytoplasmic appearance (a varying red hue that depends on the amount of haemoglobin and developmental stage) and the typically round and dense nucleus of later stages. Often the cause of the circulating nucleated forms will be shown by the accompanying cells – in the drawn example there is a teardrop form as well as a polychromatic cell (note the very similar cytoplasmic colour to the nucleated cell). The clinical examples also shows misshapen red cells and polychromasia.
	</span>		</span>

John at 10:26, 21 March 2023

2023-03-21T10:26:11Z

← Older revision		Revision as of 12:26, 21 March 2023
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	<span style="font-style:italic; font-size:90%;'' >		<span style="font-style:italic; font-size:90%;'' >
	'''Appearance''' Individual nucleated red cells. These are difficult cells to illustrate with a single image since the size, and appearance of both cytoplasm and nucleus vary with cell maturity – recognition generally depends on identifying typical cytoplasmic appearance (a varying red hue that depends on the amount of haemoglobin and developmental stage) and the typically round and dense nucleus of later stages. Often the cause of the circulating nucleated forms will be shown by the accompanying cells – in ~~this~~ example there is a sickle cell ~~and~~ a ~~irregularly contracted cell,~~ as well as a polychromatic cell (note the very similar cytoplasmic colour to the nucleated cell). ~~In this case the nRBC is shown in the context of sickle cell anaemia~~.		'''Appearance''' Individual nucleated red cells. These are difficult cells to illustrate with a single image since the size, and appearance of both cytoplasm and nucleus vary with cell maturity – recognition generally depends on identifying typical cytoplasmic appearance (a varying red hue that depends on the amount of haemoglobin and developmental stage) and the typically round and dense nucleus of later stages. Often the cause of the circulating nucleated forms will be shown by the accompanying cells – in the cartoon example there is a sickle cell there is a teardrop form as well as a polychromatic cell (note the very similar cytoplasmic colour to the nucleated cell). The clinical examples also shows misshapen red cells and polychromasia.
	</span>		</span>

John at 12:20, 20 March 2023

2023-03-20T12:20:09Z

← Older revision		Revision as of 14:20, 20 March 2023
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	<gallery mode="nolines" widths="240px" heights="240px" border="1px" >		<gallery mode="nolines" widths="240px" heights="240px" border="1px" >
	File:~~NRBC1~~.png\|link={{filepath:~~NRBC1~~.png}}		File:Nrbc1.png\|link={{filepath:Nrbc1.png}}
	File:~~NRBC2~~.jpg\|link={{filepath:~~NRBC2~~.jpg}}		File:Nrbc2.jpg\|link={{filepath:Nrbc2.jpg}}
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	~~<span style="font-size:90%"><span style="color:#808080">~~
	<gallery widths="250px" heights="250px" >		<gallery widths="250px" heights="250px" >
	File:Nrbc 1.jpg\|link={{filepath:Nrbc 1.jpg}}		File:Nrbc 1.jpg\|link={{filepath:Nrbc 1.jpg}}
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			<span style="font-style:italic; font-size:90%;'' >
	<span style="font-size:90%~~"><span style="italic"~~>
	'''Clinical image 1'''. In this case the cytoplasm of this late nucleated erythrocyte is almost identical in colour and size to the surrounding mature erythrocytes. The nucleus is very dense, round, and at the point of extrusion. Other red cells have abnormal shape, and platelets are reduced. Disorder: myelodysplasia		'''Clinical image 1'''. In this case the cytoplasm of this late nucleated erythrocyte is almost identical in colour and size to the surrounding mature erythrocytes. The nucleus is very dense, round, and at the point of extrusion. Other red cells have abnormal shape, and platelets are reduced. Disorder: myelodysplasia
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			<span style="font-style:italic; font-size:90%;'' >
	<span style="font-size:90%">
	'''Clinical image 2'''. Three very similar nucleated red cells with typical appearance of their nuclei. Some variation of size and shape is seen between the nucleated red cells - which is fairly typical. A clue to their origin is the very abnormal red cells in the background and an absence of platelets. Clinical disorder: myelodysplasia with marrow fibrosis		'''Clinical image 2'''. Three very similar nucleated red cells with typical appearance of their nuclei. Some variation of size and shape is seen between the nucleated red cells - which is fairly typical. A clue to their origin is the very abnormal red cells in the background and an absence of platelets. Clinical disorder: myelodysplasia with marrow fibrosis
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			<span style="font-style:italic; font-size:90%;'' >

	<span style="font-size:90%">
	'''Clinical image 3.''' There are two erythroid precursors on the background of very abnormal erythroid cells and platelets – one very late form resembles a slightly polychromatic erythrocyte with a dense round nucleus. Also present is a large cell with primitive nuclear chromatin and nucleoli. This is an early erythroblast – recognisable by the very blue cytoplasm (packed with haemoglobin-synthesising ribosomes). Clinical disorder: myelofibrosis		'''Clinical image 3.''' There are two erythroid precursors on the background of very abnormal erythroid cells and platelets – one very late form resembles a slightly polychromatic erythrocyte with a dense round nucleus. Also present is a large cell with primitive nuclear chromatin and nucleoli. This is an early erythroblast – recognisable by the very blue cytoplasm (packed with haemoglobin-synthesising ribosomes). Clinical disorder: myelofibrosis
	</span>		</span>

John at 12:17, 20 March 2023

2023-03-20T12:17:50Z

← Older revision		Revision as of 14:17, 20 March 2023
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	----		----
	'''Causes'''		'''Causes'''


	<div style="width: 95%; overflow: auto; border: 1px solid navy; font-size:100%">		<div style="width: 95%; overflow: auto; border: 1px solid navy; font-size:100%">
			{\| class="wikitable" style="color:black; background-color:#ffffff;" cellpadding="15"
	{\| class="wikitable"
	!colspan="1"\|'''NORMAL INDIVIDUALS'''		!colspan="1"\|'''NORMAL INDIVIDUALS'''
	\|-		\|-

John at 12:17, 20 March 2023

2023-03-20T12:17:05Z

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	<~~span style~~="~~font-size:90%~~">~~<span style~~=~~"color~~:~~#808080"~~>		<gallery mode="nolines" widths="240px" heights="240px" border="1px" >
			File:NRBC1.png\|link={{filepath:NRBC1.png}}
			File:NRBC2.jpg\|link={{filepath:NRBC2.jpg}}
			</gallery>

	~~[[File:NRBC montage.png\|180px\|\|link=]]~~

			<span style="font-style:italic; font-size:90%;'' >
	<span style="font-size:90%">
	'''Appearance''' Individual nucleated red cells. These are difficult cells to illustrate with a single image since the size, and appearance of both cytoplasm and nucleus vary with cell maturity – recognition generally depends on identifying typical cytoplasmic appearance (a varying red hue that depends on the amount of haemoglobin and developmental stage) and the typically round and dense nucleus of later stages. Often the cause of the circulating nucleated forms will be shown by the accompanying cells – in this example there is a sickle cell and a irregularly contracted cell, as well as a polychromatic cell (note the very similar cytoplasmic colour to the nucleated cell). In this case the nRBC is shown in the context of sickle cell anaemia.		'''Appearance''' Individual nucleated red cells. These are difficult cells to illustrate with a single image since the size, and appearance of both cytoplasm and nucleus vary with cell maturity – recognition generally depends on identifying typical cytoplasmic appearance (a varying red hue that depends on the amount of haemoglobin and developmental stage) and the typically round and dense nucleus of later stages. Often the cause of the circulating nucleated forms will be shown by the accompanying cells – in this example there is a sickle cell and a irregularly contracted cell, as well as a polychromatic cell (note the very similar cytoplasmic colour to the nucleated cell). In this case the nRBC is shown in the context of sickle cell anaemia.
	</span>		</span>