Howell Jolly bodies - Revision history

John at 13:54, 4 April 2023

2023-04-04T13:54:13Z

← Older revision		Revision as of 15:54, 4 April 2023
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	<span style="font-style:italic; font-size:90%;'' >		<span style="font-style:italic; font-size:90%;'' >
	'''''Clinical Image 1: ''' Very frequent Howell Jolly bodies in cells showing a range of other abnormal features (excessive variation in shape and size). Note the range of sizes and positions. Clinical condition: Post-splenectomy		'''''Clinical Image 2: ''' Very frequent Howell Jolly bodies in cells showing a range of other abnormal features (excessive variation in shape and size). Note the range of sizes and positions. Clinical condition: Post-splenectomy
	</div>		</div>

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	<span style="font-style:italic; font-size:90%;'' >		<span style="font-style:italic; font-size:90%;'' >
	'''''Clinical Image 1: '''A single cell containing a Howell Jolly body, in this case there are accompanying target cells, one “boat shaped” and several dense contracted cells. Clinical condition: sickle cell disease with hyposplenism (no true sickle cells are shown on this film).		'''''Clinical Image 3: '''A single cell containing a Howell Jolly body, in this case there are accompanying target cells, one “boat shaped” and several dense contracted cells. Clinical condition: sickle cell disease with hyposplenism (no true sickle cells are shown on this film).
	</div>		</div>

John at 19:38, 28 March 2023

2023-03-28T19:38:30Z

← Older revision		Revision as of 21:38, 28 March 2023
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	<span style="font-style:italic; font-size:90%;'' >		<span style="font-style:italic; font-size:90%;'' >
	'''Images:''' In this case a single body is indicated – note the relatively large size, and purple colour. This example is offset from the centre but not peripheral – a fairly typical position for these inclusions. In ~~clinical image~~ the Howell Jolly body is ~~within a target cell (another feature~~ of hyposplenism). ~~Also look~~ for ~~other features of the hyposplenic state such as~~ irregularly contracted cells or speculated cells ~~(not shown here)~~ or for possible cause of hyposplenism e.g. sickle cells.		'''Images:''' In this case a single HJ body is indicated – note the relatively large size, and purple colour. This example is offset from the centre but not peripheral – a fairly typical position for these inclusions. In these examples the Howell Jolly body is accompanied by other features of hyposplenism). Look for irregularly contracted cells, target cells or speculated cells or for possible cause of hyposplenism e.g. sickle cells.
	</div>		</div>

John at 19:33, 28 March 2023

2023-03-28T19:33:10Z

← Older revision		Revision as of 21:33, 28 March 2023
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	<gallery mode="nolines" widths="240px" heights="240px" border="1px" >		<gallery mode="nolines" widths="240px" heights="240px" border="1px" >
	File:~~HJ1~~.png\|link={{filepath:HJ1.png}}		File:HJ1A.png\|link={{filepath:HJ1.png}}
	File:~~HJ2~~.jpg\|link={{filepath:HJ2.jpg}}		File:HJ2A.jpg\|link={{filepath:HJ2.jpg}}
	</gallery>		</gallery>

John at 13:48, 19 March 2023

2023-03-19T13:48:13Z

← Older revision		Revision as of 15:48, 19 March 2023
Line 15:		Line 15:

	<span style="font-style:italic; font-size:90%;'' >		<span style="font-style:italic; font-size:90%;'' >
	'''Images:''' In this case a single body is indicated – note the relatively large size, and purple colour. This example is offset from the centre but not peripheral – a fairly typical position for these inclusions. In ~~this case~~ the Howell Jolly body ~~as accompanied by~~ a target cell ~~as a~~ feature ~~indicating~~ hyposplenism, other features of the hyposplenic state ~~may include~~ irregularly contracted cells or speculated cells (not shown here)~~. Remember also to look~~ for possible cause e.g. sickle cells.		'''Images:''' In this case a single body is indicated – note the relatively large size, and purple colour. This example is offset from the centre but not peripheral – a fairly typical position for these inclusions. In clinical image the Howell Jolly body is within a target cell (another feature of hyposplenism). Also look for other features of the hyposplenic state such as irregularly contracted cells or speculated cells (not shown here) or for possible cause of hyposplenism e.g. sickle cells.
	</div>		</div>

John at 14:08, 17 March 2023

2023-03-17T14:08:40Z

← Older revision		Revision as of 16:08, 17 March 2023
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	'''Appearance'''		'''Appearance'''

	Small blue/purple fragments generally rounded – their colour and position reflects their origin as retained fragments of the cell nucleus that most often they are single and relatively centrally placed. They have relatively large size compared with other inclusions (usually 0.5-1.0μM in diameter compared with a typical erythrocyte diameter of 7.~~5M~~).		Small blue/purple fragments generally rounded – their colour and position reflects their origin as retained fragments of the cell nucleus that most often they are single and relatively centrally placed. They have relatively large size compared with other inclusions (usually 0.5-1.0μM in diameter compared with a typical erythrocyte diameter of 7.5μM).

John at 15:11, 14 March 2023

2023-03-14T15:11:54Z

← Older revision		Revision as of 17:11, 14 March 2023
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	<gallery widths="250px" heights="250px" >		<gallery widths="250px" heights="250px" >
	File:HJ3.jpg\|\|link={{filepath:HJ3.jpg}}		File:HJ3.jpg\|link={{filepath:HJ3.jpg}}
	</gallery>		</gallery>


			<span style="font-style:italic; font-size:90%;'' >
	~~'''Clinical Image 1'''~~		'''''Clinical Image 1: '''One almost central Howell Jolly body that is almost centrally placed – recognise by the size and colour. In this film there are also very frequent target cells and contracted cells. Clinical condition: HbSC disease with hyposplenic features
	<~~div class~~="~~toccolours mw~~-~~collapsible mw-collapsed"~~ style="font-size 80%; ~~overflow:auto;"~~>
	One almost central Howell Jolly body that is almost centrally placed – recognise by the size and colour. In this film there are also very frequent target cells and contracted cells. Clinical condition: HbSC disease with hyposplenic features
	</div>		</div>


	<gallery widths="250px" heights="250px" >		<gallery widths="250px" heights="250px" >
	File:HJ4.jpg\|\|link={{filepath:HJ4.jpg}}		File:HJ4.jpg\|link={{filepath:HJ4.jpg}}
	</gallery>		</gallery>


			<span style="font-style:italic; font-size:90%;'' >
			'''''Clinical Image 1: ''' Very frequent Howell Jolly bodies in cells showing a range of other abnormal features (excessive variation in shape and size). Note the range of sizes and positions. Clinical condition: Post-splenectomy
			</div>

	~~'''Clinical Image 2:'''~~
	~~<div class="toccolours mw-collapsible mw-collapsed" style="font-size 80%; overflow:auto;">~~
	Very frequent Howell Jolly bodies in cells showing a range of other abnormal features (excessive variation in shape and size). Note the range of sizes and positions. Clinical condition: Post-splenectomy
	~~</div>~~

	<gallery widths="250px" heights="250px" >		<gallery widths="250px" heights="250px" >
	File:HJ5.jpg\|\|link={{filepath:HJ5.jpg}}		File:HJ5.jpg\|link={{filepath:HJ5.jpg}}
	</gallery>		</gallery>


	~~'''Clinical Image 3:'''~~		<span style="font-style:italic; font-size:90%;'' >
	<~~div class~~="~~toccolours mw~~-~~collapsible mw-collapsed"~~ style="font-size 80%; ~~overflow:auto;"~~>		'''''Clinical Image 1: '''A single cell containing a Howell Jolly body, in this case there are accompanying target cells, one “boat shaped” and several dense contracted cells. Clinical condition: sickle cell disease with hyposplenism (no true sickle cells are shown on this film).
	A single cell containing a Howell Jolly body, in this case there are accompanying target cells, one “boat shaped” and several dense contracted cells. Clinical condition: sickle cell disease with hyposplenism (no true sickle cells are shown on this film).
	</div>		</div>

John at 15:08, 14 March 2023

2023-03-14T15:08:54Z

← Older revision		Revision as of 17:08, 14 March 2023
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	----		----
	~~'''Further information'''~~

	~~1. [[Causes of Howell Jolly bodies''Go to Causes'']]~~

	~~2. [[Clinical Examples: Howell Jolly bodies''Go to Clinical Examples]]~~

	~~3. [[Pathobiology of Howell Jolly bodies\|Go to Pathobiology]]~~


	~~----~~

	'''Causes'''		'''Causes'''


	<div style="width: 95%; overflow: auto; border: ~~2px~~ solid navy; font-size:~~120~~%">		<div style="width: 95%; overflow: auto; border: 1px solid navy; font-size:100%">
	{\| class="wikitable" style="color:~~nay~~; background-color:#ffffff;" cellpadding="15"		{\| class="wikitable" style="color:black; background-color:#ffffff;" cellpadding="15"
	!colspan="1"\|'''HYPO'SPLENISM: Physiological'''		!colspan="1"\|'''HYPO'SPLENISM: Physiological'''
	\|-		\|-

John at 12:13, 14 March 2023

2023-03-14T12:13:19Z

@@ Line 15: / Line 15: @@
 <span style="font-style:italic; font-size:90%;'' >
-'''Images:''' In this case a single body is indicated – note the relatively large size, and purple colour. This example is offset from the centre but not peripheral – a fairly typical position for these inclusions.
+'''Images:''' In this case a single body is indicated – note the relatively large size, and purple colour. This example is offset from the centre but not peripheral – a fairly typical position for these inclusions. In this case the Howell Jolly body as accompanied by a target cell as a feature indicating hyposplenism, other features of the hyposplenic state may include irregularly contracted cells or speculated cells (not shown here). Remember also to look for possible cause e.g. sickle cells.
 </div>

John at 12:12, 14 March 2023

2023-03-14T12:12:52Z

← Older revision		Revision as of 14:12, 14 March 2023
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	~~'''Image 1'''~~		<span style="font-style:italic; font-size:90%;'' >
	<~~div class~~="~~toccolours mw-collapsible mw~~-~~collapsed"~~ style="font-size 80%; ~~overflow:auto;"~~>		'''Images:''' In this case a single body is indicated – note the relatively large size, and purple colour. This example is offset from the centre but not peripheral – a fairly typical position for these inclusions.
	In this case a single body is indicated – note the relatively large size, and purple colour. This example is offset from the centre but not peripheral – a fairly typical position for these inclusions.
	</div>		</div>

John at 12:11, 14 March 2023

2023-03-14T12:11:46Z

← Older revision		Revision as of 14:11, 14 March 2023
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			<gallery mode="nolines" widths="240px" heights="240px" border="1px" >
	<gallery widths="~~180px~~" heights="~~180px~~" >
	File:HJ1.png\|link={{filepath:HJ1.png}}		File:HJ1.png\|link={{filepath:HJ1.png}}
			File:HJ2.jpg\|link={{filepath:HJ2.jpg}}
	</gallery>		</gallery>