John at 10:50, 17 October 2023

2023-10-17T10:50:20Z

← Older revision		Revision as of 12:50, 17 October 2023
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	:<span style="color:navy">'''Diagnostic Use'''</span>		:<span style="color:navy">'''Diagnostic Use'''</span>

	*Although there are relatively few studies it is clear that ~~strog~~ expression of CD71 may indicate erythrid differentiation of blast cells		*Although there are relatively few studies it is clear that strong expression of CD71 may indicate erythrid differentiation of blast cells
	*However there is reported expression at lower levels on ~~commonly~~ other AML types, and less frequently in ALL nd MPAL so interpretation requires care		*However there is reported expression at lower levels on other AML types, and less frequently on ALL nd MPAL cells so interpretation requires care



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John: Created page with "
:'''Summary''' :CD71 has value in the recognition of erythroid differentiation in AML where expression levels can be strong. However, it is not fully specific and may also be a maker of high levels of proliferation. Expression is frequent on other AML subtypes including APL and other lineages including cases of ALL. For this reason the mark..."

2023-10-17T10:49:25Z

Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :CD71 has value in the recognition of erythroid differentiation in AML where expression levels can be strong. However, it is not fully specific and may also be a maker of high levels of proliferation. Expression is frequent on other AML subtypes including APL and other lineages including cases of ALL. For this reason the mark..."

New page

<div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;">

:<span style="color:navy">'''Summary'''</span>

:CD71 has value in the recognition of erythroid differentiation in AML where expression levels can be strong. However, it is not fully specific and may also be a maker of high levels of proliferation. Expression is frequent on other AML subtypes including APL and other lineages including cases of ALL. For this reason the marker can suport a diagnosis of erythroid differentiation but should not be considered as fully specific.

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:<span style="color:navy">'''Background'''</span>

:CD71 is the receptor for transferrin that is required by proliferating cells, but particularly by early erythroid cells (ofetn being lost as the cells mature). It can be helpful in histology of bone marrow since expression is acquired before CD235 (Gycophorin A) and is lost as the cells mature. It has value in recognising AML with erythroid differentiation, particularly if expression is strong, but is present on other subtypes so should not be regarded as specific.

:<span style="color:navy">'''Diagnostic Use'''</span>

*Although there are relatively few studies it is clear that strog expression of CD71 may indicate erythrid differentiation of blast cells
*However there is reported expression at lower levels on commonly other AML types, and less frequently in ALL nd MPAL so interpretation requires care

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CD71 - Revision history

John at 10:50, 17 October 2023