https://haematologyetc.co.uk/index.php?action=history&feed=atom&title=CD15 2026-08-29T03:21:52Z Revision history for this page on the wiki MediaWiki 1.39.0 https://haematologyetc.co.uk/index.php?title=CD15&diff=1461&oldid=prev 2023-05-30T07:57:20Z

<p>Created page with &quot; &lt;div style=&quot;background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;&quot;&gt; :&lt;span style=&quot;color:navy&quot;&gt;&#039;&#039;&#039;Summary&#039;&#039;&#039;&lt;/span&gt; :The main practical use for CD15 is for the recognition of cells that have granulocytic or monocytic features. For this reason CD15 has a role in lineage distinction in AML. CD15 is however also expressed in a range of haematological cell types and was originally described as the Lewis blood group antigen: Sialyl Lewis X....&quot;</p> <p><b>New page</b></p><div><br /> &lt;div style=&quot;background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;&quot;&gt;<br /> <br /> <br /> :&lt;span style=&quot;color:navy&quot;&gt;'''Summary'''&lt;/span&gt;<br /> <br /> :The main practical use for CD15 is for the recognition of cells that have granulocytic or monocytic features. For this reason CD15 has a role in lineage distinction in AML. CD15 is however also expressed in a range of haematological cell types and was originally described as the Lewis blood group antigen: Sialyl Lewis X. <br /> <br /> <br /> &lt;/div&gt;<br /> <br /> <br /> :&lt;span style=&quot;color:navy&quot;&gt;'''Background'''&lt;/span&gt;<br /> <br /> :CD15 is a carbohydrate important in the initial phases of cell-to-cell adhesion known in this context as E-selectin. In normal cells CD15 is constitutively expressed by granulocytes and monocytes, but not by resting lymphocytes - although induced strongly following activation. Deficiency of CD15 causes the clinical disorder Leukocyte Adhesion Deficiency Type 2.<br /> <br /> <br /> <br /> :&lt;span style=&quot;color:navy&quot;&gt;'''Diagnostic Use'''&lt;/span&gt;<br /> <br /> *In histopathology CD15 is important in the recognition of the Redd Sterberg cells of Hodgkin Lymphoma <br /> *CD15 is expressed by most cases of AML that have granulocytic or monocytic differentiation where expression may vary within the population. <br /> *CD15 should not however be regarded as an exclusive myeloid marker since it is expressed by some cases of CLL and ALL <br /> <br /> <br /> <br /> -----</div>

John