CD123 - Revision history

John at 12:43, 12 January 2024

2024-01-12T12:43:19Z

← Older revision		Revision as of 14:43, 12 January 2024
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	*In acute leukaemia its diagnostic value is limited since its expression may be variable, although high expression is seen in ''KMT2A'' rearrangements and ''FLT3-ITD'' mutations		*In acute leukaemia its diagnostic value is limited since its expression may be variable, although high expression is seen in ''KMT2A'' rearrangements and ''FLT3-ITD'' mutations
	*CD123 is also expressed by early lymphoid precursors		*CD123 is also expressed by early lymphoid precursors
	*In blastic plasmocytoid dendritic cell neoplasms (BPDCN) CD123 is frequently expressed		*In blastic plasmocytoid dendritic cell neoplasms (BPDCN) CD123 is frequently expressed and forms part of the diagnostic criteria
	*In B-LPD a '''high level''' of CD123 has value in the identification of hairy cell leukaemia where high expression is expected, though overall expression of CD123 is probably a less reliable indicator of HCL than CD103 and CD25		*In B-LPD a '''high level''' of CD123 has value in the identification of hairy cell leukaemia where high expression is expected, though overall expression of CD123 is probably a less reliable indicator of HCL than CD103 and CD25

John at 12:42, 12 January 2024

2024-01-12T12:42:40Z

← Older revision		Revision as of 14:42, 12 January 2024
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	:<span style="color:navy">'''Diagnostic Use'''</span>		:<span style="color:navy">'''Diagnostic Use'''</span>

	*In acute leukaemia its diagnostic value is limited since its expression may be variable, and it is also expressed by early lymphoid precursors		*In acute leukaemia its diagnostic value is limited since its expression may be variable, although high expression is seen in ''KMT2A'' rearrangements and ''FLT3-ITD'' mutations
			*CD123 is also expressed by early lymphoid precursors
	*In blastic plasmocytoid dendritic cell neoplasms (BPDCN) CD123 is frequently expressed		*In blastic plasmocytoid dendritic cell neoplasms (BPDCN) CD123 is frequently expressed
	*In B-LPD a '''high level''' of CD123 has value in the identification of hairy cell leukaemia where high expression is expected, though overall expression of CD123 is probably a less reliable indicator of HCL than CD103 and CD25		*In B-LPD a '''high level''' of CD123 has value in the identification of hairy cell leukaemia where high expression is expected, though overall expression of CD123 is probably a less reliable indicator of HCL than CD103 and CD25

John at 13:28, 14 June 2023

2023-06-14T13:28:01Z

← Older revision		Revision as of 15:28, 14 June 2023
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	:<span style="color:navy">'''Summary'''</span>		:<span style="color:navy">'''Summary'''</span>

	:~~xxxxx~~		:CD123 is the alpha-chain of the receptor for IL-3 IL-3ra . CD123 is expressed on many though not all leukaemic blast cells, but is largely absent from normal precursors including immature haematogones (although it is detected on more mature haematogones). Diagnostically the principle useful property of CD123 relates to its high level of expression on typical hairy cells although it can have value in other disorders (see below).


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	~~:<span style="color:navy">'''Background'''</span>~~

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	:<span style="color:navy">'''Diagnostic Use'''</span>		:<span style="color:navy">'''Diagnostic Use'''</span>

	*~~xxxxx~~		*In acute leukaemia its diagnostic value is limited since its expression may be variable, and it is also expressed by early lymphoid precursors
			*In blastic plasmocytoid dendritic cell neoplasms (BPDCN) CD123 is frequently expressed
			*In B-LPD a '''high level''' of CD123 has value in the identification of hairy cell leukaemia where high expression is expected, though overall expression of CD123 is probably a less reliable indicator of HCL than CD103 and CD25



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2023-06-14T10:07:06Z

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CD123 - Revision history

John at 12:43, 12 January 2024

John at 12:42, 12 January 2024

John at 13:28, 14 June 2023

John: Created page with " :'''Summary''' :xxxxx :'''Background''' :xxxxxx :'''Diagnostic Use''' *xxxxx -----"

John: Created page with "
:'''Summary''' :xxxxx
:'''Background''' :xxxxxx :'''Diagnostic Use''' *xxxxx -----"