Anisocytosis - Revision history

John at 12:38, 23 March 2023

2023-03-23T12:38:38Z

← Older revision		Revision as of 14:38, 23 March 2023
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	'''Derivation:''' ''From the Greek Aniso [Unequal] and Greek Cytosis [referring to a cell]''		'''Derivation:''' ''From the Greek Aniso [Unequal] and Greek Cytosis [referring to a cell]''

John at 18:29, 11 March 2023

2023-03-11T18:29:54Z

← Older revision		Revision as of 20:29, 11 March 2023
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	<gallery widths="250px" heights="250px" >		<gallery widths="250px" heights="250px" >
	File:Anisocytosis_2.jpg\|link={{filepath:~~Agglutination_2~~.jpg}}		File:Anisocytosis_2.jpg\|link={{filepath:Anisocytosis_2.jpg}}
	</gallery>		</gallery>

John at 18:28, 11 March 2023

2023-03-11T18:28:16Z

← Older revision		Revision as of 20:28, 11 March 2023
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	<gallery widths="250px" heights="250px" >		<gallery widths="250px" heights="250px" >
	File:Anisocytosis_1.jpg\|link={{filepath:~~Agglutination_1~~.jpg}}		File:Anisocytosis_1.jpg\|link={{filepath:Anisocytosis_1.jpg}}
	</gallery>		</gallery>

John at 18:27, 11 March 2023

2023-03-11T18:27:21Z

← Older revision		Revision as of 20:27, 11 March 2023
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	<gallery widths="250px" heights="250px" >		<gallery widths="250px" heights="250px" >
	File:Anisocytosis_1.jpg\|link={{filepath:~~Agglutination2~~.jpg}}		File:Anisocytosis_1.jpg\|link={{filepath:Agglutination_1.jpg}}
	</gallery>		</gallery>

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	<gallery widths="250px" heights="250px" >		<gallery widths="250px" heights="250px" >
	File:Anisocytosis_2.jpg\|link={{filepath:~~Agglutination3~~.jpg}}		File:Anisocytosis_2.jpg\|link={{filepath:Agglutination_2.jpg}}
	</gallery>		</gallery>

John at 14:22, 6 March 2023

2023-03-06T14:22:46Z

← Older revision		Revision as of 16:22, 6 March 2023
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	<span style="font-style:italic; font-size:90%;'' >		<span style="font-style:italic; font-size:90%;'' >
	'''''Clinical Image 1:''' Variation in ~~colour and~~ size ~~in this image~~ is ~~caused by a combination of severe hypochromia, polychromasia~~, and ~~partial transfusion~~. Clinical condition: ~~Partly treated severe thalassaemia (hydrops)~~''		'''''Clinical Image 1:''' Variation in size is very obvious, but why? Here the key point is that the smaller cells are in fact irregularly contracted cells and are much better desribed as such. Clinical condition: Haemoglobin C disease''
	</span>		</span>

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	<span style="font-style:italic; font-size:90%;'' >		<span style="font-style:italic; font-size:90%;'' >
	'''''Clinical Image 2:''' ~~The variable colour~~ in this case ~~reflects a dimorphic blood film with hypochromic~~ and ~~transfused~~ cells - ~~more accurately described as dimorphic~~. Clinical condition: ~~transfused severe iron~~ deficiency.''		'''''Clinical Image 2:''' More vaiability in size, in this case caused by enlarged and slightly ovoid cells - oval macrocytes. Clinical condition: B12 deficiency.''
	</span>		</span>

John at 14:19, 6 March 2023

2023-03-06T14:19:03Z

← Older revision		Revision as of 16:19, 6 March 2023
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	'''Description'''		'''Description'''

	Like ~~anisochromia~~, this simple term simply describes variation between cells – in this case their size when flattened on blood smears; the term is often used as a “catch all” description, but lacks value since it does not describe how cells vary (e.g. large and normal, small and normal etc) or the type of cells involved.		Like poikilocytosis, this simple term simply describes variation between cells – in this case their size when flattened on blood smears; the term is often used as a “catch all” description, but lacks value since it does not describe how cells vary (e.g. large and normal, small and normal etc) or the type of cells involved.


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	<span style="font-style:italic; font-size:90%;'' >		<span style="font-style:italic; font-size:90%;'' >
	'''Appearance:''' The key points are that ~~the red cell groups are very irregular. In many cases they~~ will ~~include cells that~~ have ~~been damaged by the underlying immunological process~~ (~~shown in the cartoon image as a spherocyte and irregularly contracted cell with the agglutinated group~~). A small image from a clinical case is shown for comparison.		'''Appearance:''' The key points are that different cells have variability in size, often such cells will also have variability in shape (poikilocytosis). A small image from a clinical case is shown for comparison.
	</span>		</span>

John at 14:16, 6 March 2023

2023-03-06T14:16:36Z

← Older revision		Revision as of 16:16, 6 March 2023
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	<gallery mode="nolines" widths="240px" heights="240px" border="1px" >		<gallery mode="nolines" widths="240px" heights="240px" border="1px" >
	File:RC_C_anisocytosis_G.~~png~~\|link={{filepath:RC_C_anisocytosis_G.~~png~~}}		File:RC_C_anisocytosis_G.jpg\|link={{filepath:RC_C_anisocytosis_G.jpg}}
	File:RC_F_anisocytosis_G.jpg\|link={{filepath:RC_F_anisocytosis_G.jpg}}		File:RC_F_anisocytosis_G.jpg\|link={{filepath:RC_F_anisocytosis_G.jpg}}
	</gallery>		</gallery>

John at 14:00, 6 March 2023

2023-03-06T14:00:57Z

← Older revision		Revision as of 16:00, 6 March 2023
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	'''Derivation:''' ''From the Greek Aniso ~~(unequal)~~ and Greek ~~Chromia (~~referring to ~~colour or shade)~~''		'''Derivation:''' ''From the Greek Aniso [Unequal] and Greek Cytosis [referring to a cell]''

	----		----
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	'''Description'''		'''Description'''

	~~This is a~~ simple term ~~that~~ describes variation ~~of colour~~ between ~~the red~~ cells on blood smears; the term does not ~~imply~~ the ~~nature~~ of ~~that variation or a pathological cause – just that different red cell have a different shade!~~		Like anisochromia, this simple term simply describes variation between cells – in this case their size when flattened on blood smears; the term is often used as a “catch all” description, but lacks value since it does not describe how cells vary (e.g. large and normal, small and normal etc) or the type of cells involved.


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	<gallery mode="nolines" widths="240px" heights="240px" border="1px" >		<gallery mode="nolines" widths="240px" heights="240px" border="1px" >
	File:~~RC_C_anisochromia_G~~.png\|link={{filepath:~~RC_C_anisochromia_G~~.png}}		File:RC_C_anisocytosis_G.png\|link={{filepath:RC_C_anisocytosis_G.png}}
	File:~~RC_F_anisochromia_G~~.jpg\|link={{filepath:~~RC_F_anisochromia_G~~.jpg}}		File:RC_F_anisocytosis_G.jpg\|link={{filepath:RC_F_anisocytosis_G.jpg}}
	</gallery>		</gallery>

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	----		----


			'''Significance'''


			Although a non-specific term there is a value in recognising anisocytosis: on a normal smear red cells present a fairly uniform population. In disease states, one of the first changes noticed by the morphologist is an increased variation either in cell shape or cell size. Anisocytosis should not be regarded as a diagnosis, and the term generally has little value to clinicians. However, for a morphologist spotting this variation should be an indication to look further.


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	~~The main pitfall~~ is ~~that the~~ term is ~~selected to describe~~ the appearances of a film but falls short of describing what is happening: cells that may contribute to variation in color may include: dense hyperchromic erythrocytes, hypochromic erythrocytes, reticulocytes or stippled cells – these should be ~~identified individually.~~		Always make sure there is not a better term to use than anisocytosis – why is there variability in size? Could the appearances better be described by another term?


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	~~The~~ term is better ~~avoided when used alone: it is generally more useful~~ to ~~indicate~~ the ~~precise types~~ of ~~cells present. The example~~ images ~~show films that could be described as “anisochromic”, but note that in each case there are more specific terms that describe the cell types that contribute to the appearance~~.		Look for anisocytosis but avoid using it as a description term on a report – it is always better to describe the nature of the variation (see images).


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	<gallery widths="250px" heights="250px" >		<gallery widths="250px" heights="250px" >
	File:~~Anisochromia_1~~.jpg\|link={{filepath:Agglutination2.jpg}}		File:Anisocytosis_1.jpg\|link={{filepath:Agglutination2.jpg}}
	</gallery>		</gallery>

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	<gallery widths="250px" heights="250px" >		<gallery widths="250px" heights="250px" >
	File:~~Anisochromia_2~~.jpg\|link={{filepath:Agglutination3.jpg}}		File:Anisocytosis_2.jpg\|link={{filepath:Agglutination3.jpg}}
	</gallery>		</gallery>

John: Created page with " '''Derivation:''' ''From the Greek Aniso (unequal) and Greek Chromia (referring to colour or shade)'' ---- '''Description''' This is a simple term that describes variation of colour between the red cells on blood smears; the term does not imply the nature of that variation or a pathological cause – just that different red cell have a different shade! File:RC_C_anisochromia_G.png|link={{fi..."

2023-03-06T13:54:24Z

Created page with " '''Derivation:''' ''From the Greek Aniso (unequal) and Greek Chromia (referring to colour or shade)'' ---- '''Description''' This is a simple term that describes variation of colour between the red cells on blood smears; the term does not imply the nature of that variation or a pathological cause – just that different red cell have a different shade! <gallery mode="nolines" widths="240px" heights="240px" border="1px" > File:RC_C_anisochromia_G.png|link={{fi..."

New page

'''Derivation:''' ''From the Greek Aniso (unequal) and Greek Chromia (referring to colour or shade)''

----

'''Description'''

This is a simple term that describes variation of colour between the red cells on blood smears; the term does not imply the nature of that variation or a pathological cause – just that different red cell have a different shade!

<gallery mode="nolines" widths="240px" heights="240px" border="1px" >
File:RC_C_anisochromia_G.png|link={{filepath:RC_C_anisochromia_G.png}}
File:RC_F_anisochromia_G.jpg|link={{filepath:RC_F_anisochromia_G.jpg}}
</gallery>


'''Appearance:''' The key points are that the red cell groups are very irregular. In many cases they will include cells that have been damaged by the underlying immunological process (shown in the cartoon image as a spherocyte and irregularly contracted cell with the agglutinated group). A small image from a clinical case is shown for comparison.


----

'''Pitfalls'''

The main pitfall is that the term is selected to describe the appearances of a film but falls short of describing what is happening: cells that may contribute to variation in color may include: dense hyperchromic erythrocytes, hypochromic erythrocytes, reticulocytes or stippled cells – these should be identified individually.

'''Recommendation'''

The term is better avoided when used alone: it is generally more useful to indicate the precise types of cells present. The example images show films that could be described as “anisochromic”, but note that in each case there are more specific terms that describe the cell types that contribute to the appearance.

'''Gallery'''


'''''Clinical Image 1:''' Variation in colour and size in this image is caused by a combination of severe hypochromia, polychromasia, and partial transfusion. Clinical condition: Partly treated severe thalassaemia (hydrops)''


<gallery widths="250px" heights="250px" >
File:Anisochromia_1.jpg|link={{filepath:Agglutination2.jpg}}
</gallery>


'''''Clinical Image 2:''' The variable colour in this case reflects a dimorphic blood film with hypochromic and transfused cells - more accurately described as dimorphic. Clinical condition: transfused severe iron deficiency.''


<gallery widths="250px" heights="250px" >
File:Anisochromia_2.jpg|link={{filepath:Agglutination3.jpg}}
</gallery>

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