Use of panels in lymphoproliferative disorders
Click the name of the disorder for detailed information
The immunophenotype of ATLL is not fully distinctive, but most frequently presents as CD4-expressing T cells with variable and low expression of CD7 and CD3, but bright expression of CD25.
B-PLL has no entirely specific marker pattern, and the immunophenotype overlaps with related conditions. However, features of the immunophenotype may suggest or support diagnosis of this condition
The immunophenotype of CLL may be entirely typical allowing confident diagnosis. However, a significant proportion of CLL cases will express atypical markers
FL has precise immunophenotype, but there are significant elements of the immunophenotype that suggest the diagnosis. Confirmation then requires correlation with clinical and pathological features
HCL has a characteristic immunophenotype phenotype that allows diagnosis with some certainty in typical disease. There is however an overlap with the variant form of HCL and to a lesser extent marginal zone lymphoma.
There is a significant variability in phenotype within the different MZL types and overlap with featureswith other disorders
A clonal lymphocyte population where the circulating number of clonal B cells and clinical features are is insufficient to diagnose a lymphoproliferative disorder
Sometimes a difficult diagnosis by immunophenotype, often requires a combined diagnostic approach
Sézary cells typically have the immunophenotype of mature CD4 T cells expressing an α/β TCR. In most cases the phenotype will have additional aberrant features that identify the cells as being abnormal. CD7 or CD26 are the most frequent aberrant antigens, although there is no absolutely specific pattern of abnormality.