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Molecular quizzes

From www.haematologyetc.co.uk


Quiz 1: Ph-negative myeloproliferative neoplasms


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Learning objectives

1. Be aware of the importance of molecular testing in the diagnosis of myeloproliferative neoplasms

2. Be able to name the common molecular mutations in polycythemia vera, essential thrombocythemia and primary myelofibrosis

3. Understand the basic molecular pathogenesis of the above

4. Understand the rationale of molecular testing algorithms for these conditions

5. Be aware of major implications of JAK2, CALR, MPL mutations on disease phenotype and treatment options



Before attempting this quiz, you may wish to review the following pages:

JAK2

CALR

MPL

Molecular Haematology

Genomic analysis at Manchester Foundation Trust



Further resources


Polycythemia vera diagnosis



ET and PMF diagnosis




Quiz 2: Acute myeloid leukaemia - UNDER CONSTRUCTION


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Learning objectives

1. Be aware of the importance of molecular testing in the diagnosis of acute myeloid leukaemia

2. Be able to name some of the common molecular mutations in AML, particularly those whose presence defines WHO classification

3. Understand the basic molecular pathogenesis of common molecular mutations in AML

4. Be aware of major clinical and therapeutic implications of common molecular mutations in AML


You may wish to review the following page:

Myeloid panels (NGS)