Gene affected:
ARAF - member of the RAF gene famil (from viral origin rapidly accelerated fibrosarcoma gene)

Clinical significance
Low frequency mutation in a minority of NHL whose prognostic significance is unclear

Function of gene

Function of the gene: A signal protein of the Raf kinases family (part of the Ras-MAPK signalling cascade) induced by a range of cell surface receptors in lymphoid cells

NGS panel gene coverage

The panel covers the whole gene. (Chr Xp11.3)

Occurrence:and significance

ARAF is altered in <1% of non-Hodgkin lymphoma patients


GeneWiki link:
Gene Wiki entry for ARAF