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ARAF

From www.haematologyetc.co.uk



Gene affected:
ARAF - member of the RAF gene famil (from viral origin rapidly accelerated fibrosarcoma gene)


Clinical significance
Low frequency mutation in a minority of NHL whose prognostic significance is unclear



Function of gene

Function of the gene: A signal protein of the Raf kinases family (part of the Ras-MAPK signalling cascade) induced by a range of cell surface receptors in lymphoid cells


NGS panel gene coverage

The panel covers the whole gene. (Chr Xp11.3)



Occurrence:and significance


ARAF is altered in <1% of non-Hodgkin lymphoma patients



Links

GeneWiki link:
Gene Wiki entry for ARAF