Actions

Difference between revisions of "Vacuolation"

From www.haematologyetc.co.uk

Line 8: Line 8:
 
[[File:Va3.jpg|leftt|250px|link=]]
 
[[File:Va3.jpg|leftt|250px|link=]]
 
[[File:Va4.jpg|leftt|250px|link=]]
 
[[File:Va4.jpg|leftt|250px|link=]]
 +
  
 
'''''Vacuolation :''' The first two images show early vacuolation in activated neutrophils with small vacuoles (images 1 and 2). The next two images arise from specific infection. In the first of these (image 3), both neutrophils have large vacuoles and show signs of exhaustion/apoptosis. The final image (image 4) shows a heavily vacuolated containing phagocytosed bacteria''
 
'''''Vacuolation :''' The first two images show early vacuolation in activated neutrophils with small vacuoles (images 1 and 2). The next two images arise from specific infection. In the first of these (image 3), both neutrophils have large vacuoles and show signs of exhaustion/apoptosis. The final image (image 4) shows a heavily vacuolated containing phagocytosed bacteria''

Revision as of 16:38, 9 November 2019

Appearance:

Pale staining, irregular areas where granules are excluded. These are most often seen in reactive cells, in combination with pronounced granulation and often Dohle bodies, and typically have irregular size and position; they may sometimes contain debris or organisms.


leftt leftt leftt leftt


Vacuolation : The first two images show early vacuolation in activated neutrophils with small vacuoles (images 1 and 2). The next two images arise from specific infection. In the first of these (image 3), both neutrophils have large vacuoles and show signs of exhaustion/apoptosis. The final image (image 4) shows a heavily vacuolated containing phagocytosed bacteria



Cause:

Most commonly vacuolation arises during bacterial infection or G-CSF treatment (although it may occur in a range of systemic toxic states). The vacuoles are believed to represent increased phagocytic activity.


Distinguish from:

  • An artefact of delayed film preparation (often the vacuoles are smaller and more uniform)
  • Congenital - neutral lipid storage disease (Jordans' anomaly)

(note that in both these cases the signs of neutrophil activation are generally absent)