Actions

Difference between revisions of "Vacuolation"

From www.haematologyetc.co.uk

(Created page with "Appearance: Pale staining, irregular areas where granules are excluded. These are most often seen in reactive cells, in combination with pronounced granulation and often Dohle...")
 
(One intermediate revision by the same user not shown)
Line 1: Line 1:
Appearance: Pale staining, irregular areas where granules are excluded. These are most often seen in reactive cells, in combination with pronounced granulation and often Dohle bodies, and typically have irregular size and position; they may sometimes contain debris or organisms.
+
'''Appearance:'''
  
Cause: Most commonly vacuolation arises during bacterial infection or G-CSF treatment (although it may occur in a range of systemic toxic states). The vacuoles are believed to represent increased phagocytic activity.  
+
Pale staining, irregular areas where granules are excluded. These are most often seen in reactive cells, in combination with pronounced granulation and often Dohle bodies, and typically have irregular size and position; they may sometimes contain debris or organisms.  
  
Distinguish from:
+
----
  
An artefact of delayed film preparation (often the vacuoles are smaller and more uniform)
+
----
Congenital - neutral lipid storage disease (Jordans' anomaly)
+
 
 +
 
 +
'''Cause:'''
 +
 
 +
Most commonly vacuolation arises during bacterial infection or G-CSF treatment (although it may occur in a range of systemic toxic states). The vacuoles are believed to represent increased phagocytic activity.
 +
 
 +
 
 +
'''Distinguish from:'''
 +
 
 +
*An artefact of delayed film preparation (often the vacuoles are smaller and more uniform)
 +
*Congenital - neutral lipid storage disease (Jordans' anomaly)
  
 
(note that in both these cases the signs of neutrophil activation are generally absent)
 
(note that in both these cases the signs of neutrophil activation are generally absent)

Revision as of 16:30, 9 November 2019

Appearance:

Pale staining, irregular areas where granules are excluded. These are most often seen in reactive cells, in combination with pronounced granulation and often Dohle bodies, and typically have irregular size and position; they may sometimes contain debris or organisms.




Cause:

Most commonly vacuolation arises during bacterial infection or G-CSF treatment (although it may occur in a range of systemic toxic states). The vacuoles are believed to represent increased phagocytic activity.


Distinguish from:

  • An artefact of delayed film preparation (often the vacuoles are smaller and more uniform)
  • Congenital - neutral lipid storage disease (Jordans' anomaly)

(note that in both these cases the signs of neutrophil activation are generally absent)