TCRαβ: Difference between revisions
From haematologyetc.co.uk
(Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :In the detection of haematological malignancy the purpose of detecting γδ T cells is to define particular T cell lymphomas (αβ T cells strongly predominate in normal blood). However care must be taken when small populations of γδ T cells are detected however, since these may arise in response to viral or other immune r...") |
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:<span style="color:navy">'''Summary'''</span> | :<span style="color:navy">'''Summary'''</span> | ||
: | :The αβ TCR is the primary form in health accounting for around 95% of circulating T cells. Alteration of that normal expression pattern may suggest a neoplastic or inflammatory disorder | ||
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:<span style="color:navy">'''Background'''</span> | :<span style="color:navy">'''Background'''</span> | ||
:T cell receptor (TCR) | :The αβ chains expressed are expressed as part of the T-cell receptor (TCR) complex - these are the antigen recognising parts of the complex. T cells expressing this receptor are referred to as αβ T cells. | ||
:<span style="color:navy">'''Diagnostic Use'''</span> | :<span style="color:navy">'''Diagnostic Use'''</span> | ||
* | *Significant populations expressing gd chains may indicate autoimmune or inflammaotory disease | ||
*γδ restriction or predominance may suggest a γδ lymphoma | |||
*Absence of αβ or γδ is found in NK lineage disorders | |||
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Latest revision as of 21:27, 14 May 2023
- Summary
- The αβ TCR is the primary form in health accounting for around 95% of circulating T cells. Alteration of that normal expression pattern may suggest a neoplastic or inflammatory disorder
- Background
- The αβ chains expressed are expressed as part of the T-cell receptor (TCR) complex - these are the antigen recognising parts of the complex. T cells expressing this receptor are referred to as αβ T cells.
- Diagnostic Use
- Significant populations expressing gd chains may indicate autoimmune or inflammaotory disease
- γδ restriction or predominance may suggest a γδ lymphoma
- Absence of αβ or γδ is found in NK lineage disorders