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Storage changes in malaria: Difference between revisions

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(Created page with "<span style="color:navy>'''Description'''</span> The male and female gametocytes of the malarial parasite may continue to mature in stored blood, in particular the pH change and temperature change may resemble changes normally encountered in the mosquito stomach, where the male gametocyte releases the microgametes as part of sexual replication. This process can be detected in some stored cases. ---- Early trophozoites: <gallery mode="nolines" widths="220px" heights...")
 
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The male and female gametocytes of the malarial parasite may continue to mature in stored blood, in particular the pH change and temperature change may resemble changes normally encountered in the mosquito stomach, where the male gametocyte releases the microgametes as part of sexual replication. This process can be detected in some stored cases.
If collected blood is not immediately prepared into a blood film the parasites may continue to develop.  


 
In the initial stage this simply may involve ring forms thickening and becoming less easy to assign to a species. Later however, the lower pH and lower temperature of stored blood may begin to resemble changes normally encountered in the mosquito stomach, this may cause the male gametocyte to develop and release the male sexual forms "microgametes" that are normally formed in the mosquito stomach as part of sexual replication. These forms may be detected in blood and can be a source of confusion unless you are familiar with them.
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Early trophozoites:
 
 
<gallery mode="nolines" widths="220px" heights="220px" >
File:MSi1.jpg|small or normal ''P.malariae (round)|link={{filepath:|MSi1.jpg}}
File:MSi3.jpg|normal sized ''P.falciparum'' (round)|link={{filepath:MSi3.jpg}}
File:MSi5.jpg|Normal or enlarged ''P.ovale'' (may become ovoid)|link={{filepath:MSi5.jpg}}
File:MSi7.jpg|generally enlarged ''P.vivax'' (may become irregular)|link={{filepath:MSi7.jpg}}
</gallery>
 
 
 
 
 
 
<gallery mode="nolines" widths="220px" heights="220px" >
File:Msi2.jpg|A|link={{filepath:|MSi1.jpg}}
File:.jpg|B|link={{filepath:MSi2.jpg}}
File:MSi6.jpg|C|link={{filepath:MSi3.jpg}}
File:.jpg|D|link={{filepath:MSi4.jpg}}
</gallery>
 
Images of red cell size of late trophozoites small ''P.malariae'' (A),  unchanged ''P.falciparum'' (B), enlarged and elongated ''P.ovale'' (C), enlarged and irregular ''P.vivax'' (D)
 
 
 
 
 
<span style="color:navy>'''Species significance'''</span>
 
 
This is an artefact appearance that can confirm a malarial infection but should not be used to infer a species
 
 
 
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Revision as of 16:43, 27 April 2024

Description


If collected blood is not immediately prepared into a blood film the parasites may continue to develop.

In the initial stage this simply may involve ring forms thickening and becoming less easy to assign to a species. Later however, the lower pH and lower temperature of stored blood may begin to resemble changes normally encountered in the mosquito stomach, this may cause the male gametocyte to develop and release the male sexual forms "microgametes" that are normally formed in the mosquito stomach as part of sexual replication. These forms may be detected in blood and can be a source of confusion unless you are familiar with them.

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