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Polyclonal B lymphocytosis

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Polyclonal B lymphocytosis:

  • Reactions associated with B-lymphoid expansion – the uncommon polyclonal B-lymphocytosis, the characteristic cell has a strongly bi-lobed nucleus although a range of forms should be present.
  • Generally arising in smokers with diagnosis confirmed by flow cytometry of the abnormal lymphocyte population


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'Polyclonal B lymphocytosis': A varied appearance easily confused with viral disorder or neoplasia. Look for the characteristic bilobed or bi-nuclear forms - flow cytometry can confirm the polyclonal B cell nature.