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Difference between revisions of "Platelet satellitism"

From www.haematologyetc.co.uk

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Revision as of 17:08, 9 November 2019


Appearance:


Platelets adhering to neutrophils – on (the flattened) blood smear they surround the edge of the cell giving a “rosette” appearance



leftt


Images of platelet satellitism: As the neutrophil is flattened and stained on the slide preparation, the platelets can be seen surrounding the edge of the cell. This gives the typical “rosette” appearance. In this case (although not always) the neutrophils may appear to be “glued together” by the attached platelets (image 1).



Cause:


Platelet satellitism is an uncommon phenomenon that occurs in samples prepared with EDTA anticoagulation, it is believed to be a complex process involving antibody and EDTA-related protein changes

Described by:


Field and Macleod (1963)


Significance:


There is no definite causal association with any disease, but if severe the rosetted platelets may not be recorded by automated counters resulting in a pseudo-thrombocytopenia. Confirmation of a relationship of agglutination with EDTA can be accomplished by viewing a smear from capillary blood or with other anticoagulants.