Plasmodium falciparum: Morphology: Difference between revisions
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'''The schizont''' | {| class="wikitable" style="border-style: solid; border-width: 5px; border-color: #023020; color:black" | ||
|colspan="1" style = "font-size:100%; color:black; background: CBD5CO |'''The schizont''' | |||
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File:PFETc.jpg|link={{filepath:PFETc.jpg}} | |||
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The asexual replication stage: | The asexual replication stage: | ||
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'''The gametocyte''' | '''The gametocyte''' | ||
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|colspan="1" style = "font-size:100%; color:black; background: CBD5CO |'''The gametocyte''' | |||
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*The single chromatin area is in the centre of the parasite, often [[Malaria pigment|pigment]] overlies or surrounds it | *The single chromatin area is in the centre of the parasite, often [[Malaria pigment|pigment]] overlies or surrounds it | ||
*Gametocytes may not be seen in many cases. | *Gametocytes may not be seen in many cases. | ||
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Revision as of 23:21, 19 March 2024
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| The early trophozoite |
The earliest developing stage, and often the only form present in this species:
- Ring forms that are fine and delicate
- Frequently the red cells contain multiple parasites
- Parasites may have a distinctive double chromatin dot (signet ring form)
- Parasites may appear on the edge of the red cell and have a flattened appearance (accolé forms)
- Affected red cells have normal size and haemoglobin content
| The late trophozoite |
The later developing stage:
- Parasites resemble early ring forms, but are thicker and slightly larger
- Additional dots and clefts in cytoplasm when stained correctly (blue and relatively low in number).
- These have a characteristic appearance and are called Maurer's dots and clefts
- Size and shape of infected red cells usually unaffected, but may become crenated
- Look for double chromatin dot, Accolé forms, multiple parasites/cell
| The schizont |
The asexual replication stage:
- Do not generally circulate in this species unless overwhelming infection
- Contain multiple asexually formed developing parasites (most frequently 8-16)
- Development is progressive: first there are multiple chromatin dots, later a distinct nucleus and cytoplasm appears
- Loose pigment may be seen in clumps between the parasites
- Red cell size is generally unaffected but haemoglobin will largely be absent (metabolised by the parasites)
The gametocyte
| The gametocyte |
The sexual replication stage (very distinctive).
- Gametocytes are elongated but are also restricted by the red cell membrane
- They appear as straight rods but frequently curve into a “banana form”
- The residual membrane (empty of haemoglobin) may appear as a "blister" to the side of the parasite
- The single chromatin area is in the centre of the parasite, often pigment overlies or surrounds it
- Gametocytes may not be seen in many cases.