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Difference between revisions of "Phagocytosis of erythrocytes"

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Revision as of 18:27, 9 November 2019

Appearance:

Phagocytosis of red cells by neutrophils opsonised by autoantibody.



Images of phagocytosis of erythrocytes by neutrophils



Cause:


The autoantibody usually affects children with viral infection, it can also occur idiopathically in adults


Described by:


Donath and Landsteiner



Significance:


The biphasic IgG autoantibody usually recognises the P antigen binds in cold areas of the body (i.e. the extremities) fixing complement to the red cells. The cells subsequently circulate to warmer areas of the body and undergo complement-mediated hemolysis. This causes intravascular haemolysis anaeamia with haemoglobin in the urine – paroxysmal cold haemoglobinuria (PCH).