Neutrophils indexed according to shared functional or structural features


General features


Normal neutrophils have a very characteristic form with easily recognised segmented nuclei and cytoplasmic granules.

This section describes:

  • The normal nuclear segmentation of neutrophils

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Artefactual features


This section describes changes that are generally regarded as being artefacts of sample storage, EDTA-anticoagulation or film preparation.

The section includes:

  • Agglutination of neutrophils
  • Apoptotic neutrophils
  • Platelet satellitism

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Reactive features


This section describes features that are most often associated with reactive states.

  • Detached nuclear fragment
  • Döhle bodies
  • Macropolycytes
  • Toxic granulation
  • Vacuolation

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Neutrophils are phagocytic cells, but the process generally occurs in tissues; however phagocytosed material in neutrophils is seen in a number of conditions.

This section includes:

  • Phagocytosis of erythrocytes
  • Phagocytosis of bacteria
  • Phagocytosis of malaria pigment

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Inherited disorders affecting neutrophils


A range of inherited conditions affect neutrophil morphology. These may affect nucleus, granulation, cytoplasm or produce added features.

This section includes:

  • Alder-Reilly anomaly
  • Chédiak-Higashi syndrome
  • Döhle-like bodies
  • Jordans' anomaly
  • Pelger-Huët anomaly

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Neoplastic involvement of neutrophils


Neoplasias (AML, MDS, MPD) can each produce characteristic morphological change to neutrophils, although some features are more specific than others.

This section includes:

  • Agranular and hypogranular neutrophils
  • Atypical nuclear shapes
  • Auer rods in neutrophils
  • Pseudo Chédiak-Higashi cells
  • Pseudo Pelger-Huët anomaly
  • Ring nuclei

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