Test and Acute leukaemia types: Difference between pages
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{| class="wikitable" style="color:black; background-color:#ffffff;" cellpadding="5" | {| class="wikitable" style="color:black; background-color:#ffffff;" cellpadding="5" | ||
!colspan="4" style = "font-size:110%; color: navy; text-align:center; background:#DEE0DE;"| | !colspan="4" style = "font-size:110%; color: navy; text-align:center; background:#DEE0DE;"|Marker patterns in typical acute myeloid leukaemia | ||
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!colspan="4" style = "font-size:90%; background:#DAE8F2"| | !colspan="4" style = "font-size:90%; background:#DAE8F2"|'''CD45 expression in AML''' | ||
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|colspan="4" style = "font-size:90%; color:black;" |Expression of CD45 is "weak" i.e. significantly less intense than normal T cells, B cells or monocytes. The typically low side scatter means that myeloid blast cells tend to form a relatively uniform population separate from lymphocytes on CD45/SSc plots. However, there is some variability releted to indididual subtypes. | |||
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!colspan="3" style = "font-size:90%; background:#DAE8F2"|'''Markers of pimitive cell type expected in AML''' | |||
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!colspan="3" style = "font-size:90%; background:white"|These markers are generally regarded as indicating less differentiated cells, so may be expressed by any acute leukaemia type. When strongly expressed they have some value in indicating T or B lineage. | |||
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|colspan="1" style = "font-size:80%; width: 4%; |'''Marker''' | |colspan="1" style = "font-size:80%; width: 4%; |'''Marker''' | ||
|colspan="1" style = "font-size:80%; width: 8%; |''' | |colspan="1" style = "font-size:80%; width: 8%; |'''Expectation''' | ||
|colspan="1" style = "font-size:80%; width: 80%; |'''Comment''' | |colspan="1" style = "font-size:80%; width: 80%; |'''Comment''' | ||
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|colspan="1" style = "font-size:90%; color:black;" | | |colspan="1" style = "font-size:90%; color:black;" |'''[[CD34]]''' | ||
|colspan="1" style = "background:#006699;"| | |colspan="1" style = "background:#006699;"| | ||
|colspan="1" style = "font-size:84%;"|Frequently expressed, most often in less differentiated forms of AML. Expression often '''less intense than in lymphoid leukaemias''' | |||
|colspan="1" style = "font-size:84%;"| | |||
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|colspan="1" style = "width: 4%; font-size:90%; color:black;" | | |colspan="1" style = "width: 4%; font-size:90%; color:black;" |'''[[TDT]]''' | ||
|colspan="1" style = "width: 8%; background:# | |colspan="1" style = "width: 8%; background:#66e0ff;"| | ||
|colspan="1" style = "font-size:80%; | |colspan="1" style = "font-size:80%;"|Expressed particularly in less differentiated forms of AML. Often on a sub-population of cells; expression usually less intense than in lymphoid leukaemias | ||
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|colspan="1" style = "font-size:90%; color:black;" | | |colspan="1" style = "font-size:90%; color:black;" |'''[[CD7]]''' | ||
|colspan="1" style = "background:#00b8e6;"| | |colspan="1" style = "background:#00b8e6;"| | ||
|colspan="1" style = "font-size:80%;"|- | |colspan="1" style = "font-size:80%;"|Similar to TdT, CD7 expression is recognised on a proportion of AML, usually those with less differentiated phenotype. Most consistently expressed in T-ALL. | ||
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!colspan="3" style = "font-size:90%; background:#DAE8F2"|'''Markers with strong lineage specificity in AML''' | |||
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!colspan="3" style = "font-size:90%; background:white"|While not expressed by all cases, MPO can be considered to be lineage-defining marker in AML (or establishing myeloid lineage in MPAL). | |||
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|colspan="1" style = "font-size: | |colspan="1" style = "font-size:80%; width: 4%; |'''Marker''' | ||
|colspan="1" style = "font-size:80%; width: 8%; |'''Expectation''' | |||
|colspan="1" style = "font-size:80%; | |colspan="1" style = "font-size:80%; width: 80%; |'''Comment''' | ||
|colspan="1" style = "font-size:80%; | |||
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|colspan="1" style = "font-size:90%; color:black;" |'''[[CD34]]''' | |||
|colspan="1" style = "background:#006699;"| | |colspan="1" style = "background:#006699;"| | ||
|colspan="1" style = "font-size:84%;"|Frequently expressed, most often in less differentiated forms of AML. Expression often '''less intense than in lymphoid leukaemias''' | |||
|colspan="1" style = "font-size:84%;"|Expression | |||
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Revision as of 13:57, 17 July 2023
Marker patterns in typical acute myeloid leukaemia | |||
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CD45 expression in AML | |||
Expression of CD45 is "weak" i.e. significantly less intense than normal T cells, B cells or monocytes. The typically low side scatter means that myeloid blast cells tend to form a relatively uniform population separate from lymphocytes on CD45/SSc plots. However, there is some variability releted to indididual subtypes. | |||
Markers of pimitive cell type expected in AML | |||
These markers are generally regarded as indicating less differentiated cells, so may be expressed by any acute leukaemia type. When strongly expressed they have some value in indicating T or B lineage. | |||
Marker | Expectation | Comment | |
CD34 | Frequently expressed, most often in less differentiated forms of AML. Expression often less intense than in lymphoid leukaemias | ||
TDT | Expressed particularly in less differentiated forms of AML. Often on a sub-population of cells; expression usually less intense than in lymphoid leukaemias | ||
CD7 | Similar to TdT, CD7 expression is recognised on a proportion of AML, usually those with less differentiated phenotype. Most consistently expressed in T-ALL. | ||
Markers with strong lineage specificity in AML | |||
While not expressed by all cases, MPO can be considered to be lineage-defining marker in AML (or establishing myeloid lineage in MPAL). | |||
Marker | Expectation | Comment | |
CD34 | Frequently expressed, most often in less differentiated forms of AML. Expression often less intense than in lymphoid leukaemias |